132430-59-2

Basic information

• Product Name: 1-benzyl-5-bromo-1H-imidazole
• Synonyms: 1-benzyl-5-bromo-1H-imidazole
• CAS NO: 132430-59-2
• Molecular Formula: C₁₀H₉BrN₂
• Molecular Weight: 237
• Mol File: 132430-59-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 76-78 °C(Solv: ethyl acetate (141-78-6))
• Boiling Point: 366.1±17.0 °C(Predicted)
• Appearance: /
• Density: 1.44±0.1 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 5.03±0.13(Predicted)
• CAS DataBase Reference: 1-benzyl-5-bromo-1H-imidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzyl-5-bromo-1H-imidazole(132430-59-2)
• EPA Substance Registry System: 1-benzyl-5-bromo-1H-imidazole(132430-59-2)

Safety Data

• Hazardous Substances Data: 132430-59-2(Hazardous Substances Data)

Usage

General Description

1-benzyl-5-bromo-1H-imidazole is a chemical compound with the molecular formula C10H9BrN2. It is a derivative of imidazole and contains a benzyl group and a bromine atom. 1-benzyl-5-bromo-1H-imidazole is commonly used in organic synthesis and pharmaceutical research due to its potential biological activity. It has been studied for its antimicrobial and antifungal properties and shows promise as a potential drug candidate. Additionally, 1-benzyl-5-bromo-1H-imidazole has been investigated for its potential use in material science, particularly for its ability to form metal complexes and coordination polymers. Overall, this chemical compound has diverse potential applications in the fields of medicine and materials.

Upstream product

• 2302-25-2 4-bromo-1 H-imidazole 
• 100-44-7 benzyl chloride 
• 100-39-0 benzyl bromide 

Relevant articles and documents

A general, practical palladium-catalyzed cyanation of (hetero)aryl chlorides and bromides

Playing it safe: The nontoxic cyanide source K4[Fe(CN) 6]×3 H2O can be used for the cyanation of (hetero)aryl halides. The application of palladacycle catalysts prevents poisoning during catalyst formation, thereby allowing for low catalyst loadings, fast reaction times, and wide heterocyclic substrate scope.

Alkylation, Acylation and Silylation of Azoles

Performing alkylation, acylation and silylation reactions in separate deprotonation and nucleophilic displacement steps allows for better control of reaction conditions and facilitates problem handling in these processes.In the alkylation of azoles the alkylating agents and solvents possess individual reaction capabilities which seem to be approximately additive.Monoalkylation occurs if the sum of the normalized reaction potentials is equal or larger than the pKa value of the azole.Dialkylation is avoided by keeping the sum of the normalized reaction potentials below the pKa value of the alkylazole.The applicability of these principles is demonstrated by the development of effective procedures for the methylation, benzylation, acetylation, methoxycarbonylation and trimethylsilylation of azoles.