132464-59-6

Basic information

• Product Name: 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propyn-1-ol
• Synonyms: 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propyn-1-ol
• CAS NO: 132464-59-6
• Molecular Formula: C₁₈H₁₃ClN₄OS
• Molecular Weight: 368.84002
• Product Categories: Aromatics;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds;Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals, Sulfur & Selenium Compounds
• Mol File: 132464-59-6.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 633°C at 760 mmHg
• Flash Point: 336.6°C
• Appearance: /
• Density: 1.45g/cm³
• Vapor Pressure: 6.83E-17mmHg at 25°C
• Refractive Index: 1.733
• Solubility: Chloroform, Dichloromethane, Methanol
• CAS DataBase Reference: 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propyn-1-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propyn-1-ol(132464-59-6)
• EPA Substance Registry System: 3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propyn-1-ol(132464-59-6)

Safety Data

• Hazardous Substances Data: 132464-59-6(Hazardous Substances Data)

Usage

Description

3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propyn-1-ol is a complex organic compound characterized by its unique molecular structure. It is a yellow solid with potential applications in the pharmaceutical industry due to its chemical properties.

Uses

Used in Pharmaceutical Industry:
3-[4-(2-Chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-2-propyn-1-ol is used as a Platelet-activating factor (PAF) antagonist for its ability to inhibit the action of PAF, which plays a role in various physiological processes and is involved in the pathogenesis of several diseases.
Additionally, it is used as an intermediate in the preparation of antiarrhythmics, which are medications designed to regulate abnormal heart rhythms. Its unique chemical structure allows it to be a valuable component in the synthesis of these drugs, potentially improving their efficacy and safety.

InChI:InChI=1/C18H13ClN4OS/c1-11-21-22-16-10-20-17(13-6-2-3-7-15(13)19)14-9-12(5-4-8-24)25-18(14)23(11)16/h2-3,6-7,9,24H,8,10H2,1H3

Upstream product

• 107-19-7 propargyl alcohol 
• 57801-81-7 brotizolam 

Downstream Products

• 132464-61-0 (Z)-4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propenyl}morpholine 
• 132464-60-9 4-{3-[4-(2-chlorophenyl)-9-methyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-2-yl]-1-oxo-2-propynyl}morpholine 

Relevant articles and documents

Thienotriazolodiazepines as platelet-activating factor antagonists. Steric limitations for the substituent in position 2

The preparations of thienotriazolodiazepines bearing a substituted ethynyl group at the 2-position, and the corresponding cis-olefins and fully saturated analogues are described. The compounds were evaluated as potential antagonists of platelet-activating