132472-31-2 Usage
Description
(3E)-2-amino-4-(phosphonomethyl)hept-3-enoic acid, also known as APH, is a chemical compound that functions as a potent and selective inhibitor of glutamate carboxypeptidase II (GCPII). This enzyme is involved in the regulation of glutamate levels within the central nervous system. APH has demonstrated a range of pharmacological properties, making it a promising candidate for the development of therapeutic agents targeting neurological disorders, cognitive impairment, and potentially cancer therapy.
Uses
Used in Pharmaceutical Industry:
(3E)-2-amino-4-(phosphonomethyl)hept-3-enoic acid is used as a therapeutic agent for the treatment of neurological disorders such as neuropathic pain and neurodegenerative diseases. Its ability to inhibit GCP II helps in modulating glutamate levels, which is crucial for managing these conditions.
Used in Cancer Therapy Research:
(3E)-2-amino-4-(phosphonomethyl)hept-3-enoic acid is being investigated for its potential use in cancer therapy. Its exact role and mechanism in this context are still under exploration, but its pharmacological properties suggest it may contribute to novel cancer treatment strategies.
Used in Neuroprotection:
(3E)-2-amino-4-(phosphonomethyl)hept-3-enoic acid is studied for its potential as a neuroprotective agent. This application aims to protect neurons from damage or death, which could be beneficial in various neurological conditions and potentially in the context of neurodegenerative diseases.
Used in Cognitive Impairment Treatment:
(3E)-2-amino-4-(phosphonomethyl)hept-3-enoic acid is also being examined for its potential role in treating cognitive impairment. Given its impact on glutamate regulation, it may help improve cognitive function in individuals affected by such impairments.
Check Digit Verification of cas no
The CAS Registry Mumber 132472-31-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,4,7 and 2 respectively; the second part has 2 digits, 3 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 132472-31:
(8*1)+(7*3)+(6*2)+(5*4)+(4*7)+(3*2)+(2*3)+(1*1)=102
102 % 10 = 2
So 132472-31-2 is a valid CAS Registry Number.
132472-31-2Relevant articles and documents
Unsaturated amino acids
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, (2008/06/13)
The invention relates to unsaturated amino acids of the formula I STR1 in which R1 represents hydroxy or etherified hydroxy, R2 represents hydrogen, alkyl, hydroxy or etherified hydroxy, R3 represents hydrogen, alkyl, haloalkyl, hydroxyalkyl, lower alkoxyalkyl, arylalkyl, lower alkenyl, halogen or aryl, R4 represents hydrogen, alkyl or aryl, R5 represents hydrogen or alkyl, R6 represents carboxy or esterified or amidated carboxy, R7 represents amino or amino substituted by alkyl or acyl, A represents unsubstituted or alkyl-substituted α,ω-alkylene having from 1 to 3 carbon atoms or represents a bond, and B represents methylene or a bond, with the proviso that A is other than a bond when B represents a bond, and salts thereof. They can be manufactured, for example, in accordance with the Michaelis-Arbuzov reaction and can be used as pharmacologically active substances.
