132515-37-8

Basic information

• Product Name: N-(2-methyl-1H-indol-5-yl)benzamide
• CAS NO: 132515-37-8
• Molecular Weight: 250.3
• Mol File: 132515-37-8.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-(2-methyl-1H-indol-5-yl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-(2-methyl-1H-indol-5-yl)benzamide(132515-37-8)
• EPA Substance Registry System: N-(2-methyl-1H-indol-5-yl)benzamide(132515-37-8)

Safety Data

• Hazardous Substances Data: 132515-37-8(Hazardous Substances Data)

Upstream product

• 7570-49-2 5-amino-2-methylindole 
• 65-85-0 benzoic acid 
• 115210-54-3 2-methyl-5-nitroindoline 
• 98-88-4 benzoyl chloride 

Relevant articles and documents

Inhibition of monoamine oxidase by indole and benzofuran derivatives

Monoamine oxidase (MAO) is an important drug target for the treatment of neurological disorders. A series of indole and benzofuran derivatives were synthesised and evaluated as inhibitors of the two MAO isoforms, MAO-A and MAO-B. In general, the derivatives were found to be selective MAO-B inhibitors with Ki values in the nanoMolar (nM) to microMolar (μM) concentration range. The most potent MAO-B inhibitor, 3,4-dichloro-N-(2-methyl- 1H-indol-5-yl)benzamide, exhibited a Ki value of 0.03 μM and was 99 fold more selective for the B isoform. We conclude that these indole and benzofuran derivatives are promising reversible MAO-B inhibitors with a possible role in the treatment of neurodegenerative diseases such as Parkinson's disease (PD).