1325219-29-1

Basic information

• Product Name: C₁₅H₁₄FNO₂S
• CAS NO: 1325219-29-1
• Molecular Weight: 291.346
• Mol File: 1325219-29-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: C₁₅H₁₄FNO₂S(CAS DataBase Reference)
• NIST Chemistry Reference: C₁₅H₁₄FNO₂S(1325219-29-1)
• EPA Substance Registry System: C₁₅H₁₄FNO₂S(1325219-29-1)

Safety Data

• Hazardous Substances Data: 1325219-29-1(Hazardous Substances Data)

Upstream product

• 624-92-0 Dimethyldisulphide 
• 33489-70-2 4-fluoro-N-(4-methoxyphenyl)benzamide 

Downstream Products

• 727664-90-6 6-fluoro-2-(4-methoxyphenyl)benzo[d]isothiazol-3(2H)-one 
• 1325219-18-8 C₁₅H₁₄FNO₃S 

Relevant articles and documents

Benzisothiazolones as modulators of macrophage migration inhibitory factor

Substituted N-phenylbenzisothiazolones have been investigated as inhibitors of the tautomerase activity of the proinflammatory cytokine MIF (macrophage migration inhibitory factor). Numerous compounds were found to possess antagonist activity in the low micromolar range with the most potent being the 6-hydroxy analog 1w. Compound 1w and the p-cyano analog 1c were also shown to exhibit significant inhibition of the binding of MIF to its transmembrane receptor CD74. Consistently, both compounds were also found to retard the MIF-dependent phosphorylation of ERK1/2 in human synovial fibroblasts.