132541-52-7 Usage
Description
Hydroxy(2-naphthyl)Methanephosphonic Acid (HNMPA) is a cell-impermeable tyrosine kinase inhibitor that selectively targets and blocks receptor serine and tyrosine phosphorylation, particularly the insulin receptor tyrosine kinase activity. It does not interfere with protein kinase C or cyclic AMP-dependent protein kinase activities, making it a specific inhibitor for certain cellular processes.
Uses
Used in Pharmaceutical Industry:
Hydroxy(2-naphthyl)Methanephosphonic Acid is used as an insulin receptor tyrosine kinase (IRTK) inhibitor for its ability to selectively block the insulin receptor tyrosine kinase activity. This selective inhibition can be beneficial in studying the role of insulin receptor signaling in various cellular processes and may have potential therapeutic applications in conditions related to insulin resistance or dysregulation.
Used in Research Applications:
HNMPA is used as a selective insulin receptor tyrosine kinase inhibitor in research settings to investigate the effects of inhibiting insulin receptor signaling on cellular functions. With an IC50 value of 200 μM in vitro, it provides a valuable tool for understanding the role of insulin receptor tyrosine kinase in cell signaling and its potential implications in disease progression.
references
[1]. baltensperger k, lewis re, woon cw, et al. catalysis of serine and tyrosine autophosphorylation by the human insulin receptor. proc natl acad sci u s a. 1992 sep 1;89(17):7885-9.[2]. moon mj, kim hy, park s, et al. insulin contributes to fine-tuning of the pancreatic beta-cell response to glucagon-like peptide-1. mol cells. 2011 oct;32(4):389-95.
Check Digit Verification of cas no
The CAS Registry Mumber 132541-52-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,5,4 and 1 respectively; the second part has 2 digits, 5 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 132541-52:
(8*1)+(7*3)+(6*2)+(5*5)+(4*4)+(3*1)+(2*5)+(1*2)=97
97 % 10 = 7
So 132541-52-7 is a valid CAS Registry Number.
132541-52-7Relevant articles and documents
Small ligands interacting with the phosphotyrosine binding pocket of the Src SH2 protein
Deprez, Pierre,Mandine, Eliane,Gofflo, Dominique,Meunier, Stephane,Lesuisse, Dominique
, p. 1295 - 1298 (2007/10/03)
Various small fragments bearing phosphate, phosphonate or phosphonic acid moieties have been prepared through parallel synthesis and their binding potencies evaluated on the Src SH2 protein using a BIAcore assay. This provided us insight into the requirement of the Src SH2 pTyr binding pocket and some promising small ligands have been characterised.
Phosphonate-containing inhibitors of tyrosine-specific protein kinases
Burke Jr.,Li,Bolen,Marquez
, p. 1577 - 1581 (2007/10/02)
Tyrosine-specific protein kinases (TPK) are important signal transducing enzymes involved in normal cellular growth and differentiation and have been implicated in the etiology of a number of human neoplastic processes. Efforts to develop agents which inh
