132606-95-2Relevant articles and documents
Chemical synthesis, purification, and characterization of 3′-5′-linked canonical cyclic dinucleotides (CDNs)
Wang, Changhao,Hao, Min,Qi, Qianqian,Chen, Yashao,Hartig, J?rg S.
, p. 41 - 59 (2019)
So far, four cyclic dinucleotides (CDNs) have been discovered as important second messengers in nature, where three canonical CDNs of c-di-GMP, c-di-AMP and c-AMP-GMP were found in bacteria containing two 3′-5′ phosphodiester linkages and one non-canonica
DC-SIGN ANTIBODY CONJUGATES COMPRISING STING AGONISTS
-
Page/Page column 202-203, (2020/05/29)
Provided herein are immunoconjugates comprising an anti-DC-SiGN antibody conjugated to a STING agonist. Also disclosed are methods of making the immunoconjugates and methods of treating cancer using the immunoconjugates.
Synthesis of All Possible Canonical (3′-5′-Linked) Cyclic Dinucleotides and Evaluation of Riboswitch Interactions and Immune-Stimulatory Effects
Wang, Changhao,Sinn, Malte,Stifel, Julia,Heiler, Anna C.,Sommershof, Annette,Hartig, J?rg S.
supporting information, p. 16154 - 16160 (2017/11/22)
The cyclic dinucleotides (CDNs) c-di-GMP, c-di-AMP, and c-AMP-GMP are widely utilized as second messengers in bacteria, where they signal lifestyle changes such as motility and biofilm formation, cell wall and membrane homeostasis, virulence, and exo-elec