132619-30-8Relevant articles and documents
THE SYNTHESIS OF (+)- AND (-)-1-BENZOYL-1,2,2a,3,4,5-HEXAHYDROBENZINDOL-4-AMINE, and PREPARATION OF LY228729
Martinelli, Michael J.,Leanna, M. Robert,Varie, David L.,Peterson, Barry C.,Kress, Thomas J.,et al.
, p. 7579 - 7582 (1990)
Racemic epoxide 5 was reacted with S-Phenylethylamine to afford diastereomers 6 and 7, from which amino alcohol 6 could be isolated directly.Aziridine formation and tandem-hydrogenolysis provided optically pure primary amine 2 (31percent from racemic 4),