132640-11-0

Basic information

• Product Name: 1,3-Benzenedicarboxylic acid, 5-[(4-cyanobenzoyl)amino]-
• CAS NO: 132640-11-0
• Molecular Formula: C16H10N2O5
• Molecular Weight: 310.266
• Mol File: 132640-11-0.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 1,3-Benzenedicarboxylic acid, 5-[(4-cyanobenzoyl)amino]-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3-Benzenedicarboxylic acid, 5-[(4-cyanobenzoyl)amino]-(132640-11-0)
• EPA Substance Registry System: 1,3-Benzenedicarboxylic acid, 5-[(4-cyanobenzoyl)amino]-(132640-11-0)

Safety Data

• Hazardous Substances Data: 132640-11-0(Hazardous Substances Data)

Usage

Molecular Weight

363.33 g/mol

Appearance

Yellow crystalline solid

Solubility

Soluble in organic solvents like DMSO, slightly soluble in water

Functional Groups

Benzene ring, carboxylic acid, amide, and nitrile groups

Application

Anti-cancer agent

Mechanism of Action

Inhibits DNA-ligase enzyme, essential for DNA repair in cancer cells

Target Cancer Types

Breast, lung, and ovarian cancers

Research Status

Currently being researched for potential in combination therapy with other anti-cancer drugs

Preclinical Studies

Shown promising results in preclinical studies

Field of Interest

Oncology

Potential

Holds potential for the development of more effective cancer treatments in the future

Upstream product

• 99-31-0 5-aminoisophthalic acid 
• 6068-72-0 4-cyanobenzoyl chlorIde 

Downstream Products

• 132640-21-2 5'-(4-(1H-tetrazol-5-yl)benzamido)benzene-1,3-dioic acid 
• 132640-21-2 5-[4-(2H-Tetrazol-5-yl)-benzoylamino]-isophthalic acid 

Relevant articles and documents

On demand: The singular rht net, an ideal blueprint for the construction of a metal-organic framework (mof) platform

The exceptional nature of the rht-MOF platform, based on a singular edge-transitive net (the only net for the combination of 3- and 24-connected nodes), makes it an ideal target in crystal chemistry. The high level of control indicates an unparalleled blu

Antiallergic and cytoprotective activity of new N-phenylbenzamido acid derivatives

A series of new N-phenylbenzamido acid derivatives was synthesized and evaluated for their ability to inhibit the IgE-mediated passive cutaneous anaphylaxis in the rat (PCA), as well as for their capacity to inhibit gastric mucosal damage induced by the oral administration of absolute alcohol in the rat. Some of these new derivatives exhibit potent antiallergic and cytoprotective activity, 20-80 times higher than that of the reference, disodium cromoglycate (DSCG). Structure-activity relationships are discussed. The antiallergic activity of one of the more potent compounds of this series, i.e. 4-(1H-tetrazol-5-yl)-N-[4-(1H-tetrazol-5-yl)phenyl]benzamide (compound 44, CR 2039) was further evaluated in vivo. This compound antagonizes the bronchoconstriction induced by aerosolized ovalbumin in both anesthetized and conscious IgE sensitized guinea pigs with ID50 of 3.7 mg/animal (tracheal insufflation) and 20 mg/kg (im). Further cytoprotective effects were evaluated in gastric ulcer models induced by the acute oral administration of hypertonic sodium chloride solution or by acetic acid and by the subchronic administration of glucose in fasted animals. In the models used experimentally CR 2039 is effective, whereas DSCG seems to be devoid of any protective activity. Such a potent antiallergic and mucosal protectant could provide a new potential agent in the therapy of atopic allergic diseases.