132658-56-1Relevant articles and documents
Latent Inhibitors. Part 7. Inhibition of Dihydro-orotate Dehydrogenase by Spirocyclopropanobarbiturates
Fraser, William,Suckling, Colin J.,Wood, Hamish C. S.
, p. 3137 - 3144 (2007/10/02)
A series of 5-spirocyclopropanobarbiturates bearing alkyl and aryl substituents on the cyclopropane ring has been synthesized.Dihydro-orotate dehydrogenase from Clostridium oroticum was shown to be inhibited by these compounds.A related series of 5-member