132776-25-1 Usage
Molecular structure
The compound has a complex molecular structure with multiple functional groups and a pyrimidine-2,4-dione core.
Stereochemistry
The compound has a specific stereochemistry with four chiral centers (2R, 3R, 4R, 5S).
Functional groups
The compound contains azide, fluoro, and trityloxymethyl functional groups.
Azide group
The presence of an azide group (N3) suggests potential reactivity and the possibility of forming covalent bonds with other molecules.
Fluoro group
The fluoro group (F) can influence the compound's lipophilicity, reactivity, and interaction with biological targets.
Trityloxymethyl group
The trityloxymethyl group (trityl = triphenylmethyl) provides steric bulk and can protect the molecule from unwanted reactions.
Pyrimidine-2,4-dione core
The core structure of the compound is a pyrimidine-2,4-dione, which is a common structural motif in various biologically active molecules.
Potential applications
The compound has potential applications in medicinal chemistry, particularly in the development of antiviral or antibacterial drugs.
Biological activities
Due to its unique structure and functional groups, the compound may have various biological activities or interactions with other molecules.
Further research
Thorough testing and analysis of the compound's properties and potential uses are necessary to fully understand its capabilities and limitations.
Pharmaceutical development
The compound is an interesting target for further research and potential pharmaceutical development, given its diverse chemical composition and potential applications.
Check Digit Verification of cas no
The CAS Registry Mumber 132776-25-1 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,2,7,7 and 6 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 132776-25:
(8*1)+(7*3)+(6*2)+(5*7)+(4*7)+(3*6)+(2*2)+(1*5)=131
131 % 10 = 1
So 132776-25-1 is a valid CAS Registry Number.
132776-25-1Relevant articles and documents
Mycobacterium tuberculosis thymidine monophosphate kinase inhibitors: Biological evaluation and conformational analysis of 2′- and 3′-modified thymidine analogues
Van Rompaey, Philippe,Nauwelaerts, Koen,Vanheusden, Veerle,Rozenski, Jef,Munier-Lehmann, Helene,Herdewijn, Piet,Van Calenbergh, Serge
, p. 2911 - 2918 (2007/10/03)
Mycobacterium tuberculosis thymidine monophosphate kinase (TMPKmt) has recently been introduced as a potential target for the structure-based design of anti-tuberculosis drugs. Based on the TMPKmt X-ray structure and previous S.A.R. studies, we synthesised the nucleoside analogues 3a-b, 6a-b, 7a-b, and 8a-b, modified in 2′- and 3′-position of the ribofuranose ring moiety. To our surprise, these analogues showed only moderate binding affinity (i.e. Ki between 118 and 1260 μM). This prompted us to investigate the conformational features of these nucleosides. We concluded that compounds of this series, especially 8a-b, are strongly biased towards the "Northern" furanose ring conformation, whereas X-ray crystallography reveals a preference of TMPKmt for the opposite "Southern" conformers. This paper covers the synthesis, biological evaluation and conformational features (i.e. preferred ring puckering) of the 2′- and 3′-modified dT analogues. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003.
