13280-07-4

Basic information

• Product Name: 4-CHLORO-2-BUTYN-1-OL
• Synonyms: 4-CHLORO-2-BUTYN-1-OL;1-chloro-2-butyn-4-ol;4-chloro-2-butyn-1-o;1-Chloro-4-hydroxybut-2-yne;4-Chlorobut-2-yn-1-ol;1-Chloro-4-hydroxy-2-butyne
• CAS NO: 13280-07-4
• Molecular Formula: C₄H₅ClO
• Molecular Weight: 104.53
• EINECS: -0
• Product Categories: Alkynes;Building Blocks;Chemical Synthesis;Internal;Organic Building Blocks
• Mol File: 13280-07-4.mol
• Article Data: 44

Chemical Properties

• Boiling Point: 92-34°C 13mm
• Flash Point: 92-94°C/13mm
• Appearance: /
• Density: 1,213 g/cm3
• Vapor Pressure: 0.0866mmHg at 25°C
• Refractive Index: 1.5004
• Storage Temp.: ?20°C
• Solubility: Miscible with diethyl ether.
• PKA: 12.92±0.10(Predicted)
• BRN: 1098382
• CAS DataBase Reference: 4-CHLORO-2-BUTYN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-2-BUTYN-1-OL(13280-07-4)
• EPA Substance Registry System: 4-CHLORO-2-BUTYN-1-OL(13280-07-4)

Safety Data

• Hazard Codes: Xn
• Statements: 10-20/21/22-36/37/38
• Safety Statements: 16-26-36
• RIDADR: 1987
• WGK Germany: 3
• RTECS: ES0725000
• PackingGroup: II
• Hazardous Substances Data: 13280-07-4(Hazardous Substances Data)

Usage

Uses

4-Chloro-2-butyn-1-ol is used in preparatiion of allenes.

InChI:InChI=1/C4H5ClO/c5-3-1-2-4-6/h6H,3-4H2

Upstream product

• 110-65-6 1,4-dihydroxybut-2-yne 
• 50-00-0 formaldehyd 
• 624-65-7 2-propynyl chloride 
• 112-99-2 Dioctadecylamine 
• 821-10-3 1,4-Dichloro-2-butyne 

Downstream Products

• 20739-58-6 2-octyn-1-ol 
• 4835-21-6 (3-nitro-phenyl)-carbamic acid-(4-chloro-but-2-ynyl ester) 
• 764-60-3 hex-2-yn-1-ol 
• 28495-06-9 4-phenyl-2-butyn-1-ol 
• 18913-31-0 2,3-butadien-1-ol 
• 13280-03-0 4-chlorobut-2-ynoic acid 
• 4835-23-8 (4-chloro-phenyl)-carbamic acid-(4-chloro-but-2-ynyl ester) 
• 4835-22-7 (2-chloro-phenyl)-carbamic acid-(4-chloro-but-2-ynyl ester) 
• 4836-78-6 (2-nitro-phenyl)-carbamic acid-(4-chloro-but-2-ynyl ester) 
• 4835-20-5 (4-nitro-phenyl)-carbamic acid-(4-chloro-but-2-ynyl ester) 
• 14597-26-3 4-dimethylamino-2-butyn-1-ol 
• 10575-25-4 4-diethylamino-2-butyn-1-ol 
• 118728-06-6 S-(4-hydroxy-but-2-ynyl)-isothiourea; hydrochloride 
• 34905-11-8 4-(4-methylphenyl)-2-butyn-1-ol 

Relevant articles and documents

Synthesis and functional pharmacological effects on human bronchi of 20-hydroxyeicosatetraenoic acid

We have synthesized 20-hydroxyeicosatetraenoic acid (20-HETE) following a new route and delineated its functional effects in human bronchi. Isometric tension measurements were performed, and they demonstrated that synthetic 20-HETE induced a concentration-dependent relaxant effect in ASM on resting tone and on bronchi pre-contracted with methacholine.

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Dearomative Cycloadditions Utilizing an Organic Photosensitizer: An Alternative to Iridium Catalysis

A highly efficient, cheap, and organic alternative to the commonly used iridium photosensitizer (Ir[dF(CF3)ppy]2(dtbpy))PF6 ([Ir-F]) is presented for visible-light energy transfer catalysis. The organic dye 2CzPN surpasses [Ir-F] in selectivity while at t

Rhodium-Catalyzed Diastereo- And Enantioselective Tandem Spirocyclization/Reduction of 3-Allenylindoles: Access to Functionalized Vinylic Spiroindolines

A highly selective rhodium-catalyzed tandem spirocyclization/reduction of 3-allenylindoles is reported. By employing a Hantzsch ester as reductant, vinylic spiroindolines are obtained in excellent yields as well as diastereo- and enantioselectivity. In addition, the reaction's synthetic utility is highlighted by broad functional group compatibility and exemplified by a gram scale reaction with subsequent assorted transformations.