132800-13-6

Basic information

• Product Name: Piperazine, 1-cyclobutyl-
• Synonyms: Piperazine, 1-cyclobutyl-;N-cyc-Bu-piperazine
• CAS NO: 132800-13-6
• Molecular Formula: C₈H₁₆N₂
• Molecular Weight: 140.22604
• Mol File: 132800-13-6.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 217℃
• Flash Point: 92℃
• Appearance: /
• Density: 1.014
• Storage Temp.: 2-8°C(protect from light)
• PKA: 9.28±0.10(Predicted)
• CAS DataBase Reference: Piperazine, 1-cyclobutyl-(CAS DataBase Reference)
• NIST Chemistry Reference: Piperazine, 1-cyclobutyl-(132800-13-6)
• EPA Substance Registry System: Piperazine, 1-cyclobutyl-(132800-13-6)

Safety Data

• Hazardous Substances Data: 132800-13-6(Hazardous Substances Data)

Usage

General Description

Piperazine, 1-cyclobutyl- is a chemical compound that belongs to the piperazine family, which is commonly used in the pharmaceutical industry. It is characterized by a cyclobutyl group attached to the piperazine ring, giving it specific properties and potential biological activities. Piperazine derivatives are known for their various pharmacological activities, including antipsychotic, anxiolytic, and analgesic effects. This particular compound may have potential applications in the development of new drugs for treating various conditions and diseases. Its specific chemical structure and properties make it a valuable building block for medicinal chemistry research and drug discovery.

Upstream product

• 485798-62-7 4-cyclobutyl-piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 923931-84-4 1-{4-[4-(4-cyclobutyl-piperazine-1-carbonyl)-piperazin-1-yl]-phenyl}-ethanone 
• 1035271-09-0 ethyl 4-(4-cyclobutylpiperazin-1-yl)benzoate 
• 1056000-53-3 [3-(4-cyclobutyl-piperazine-1-ylmethyl)-1H-indol-6-yl]-(4-phenyl-piperidin-1-yl)-methanone 
• 1227610-20-9 benzyl 2-(4-cyclobutylpiperazine-1-carbonyl)-7-azaspiro[3.5]nonane-7-carboxylate 
• 1238877-83-2 benzyl 3-[(4-cyclobutylpiperazin-1-yl)carbonyl]azetidine-1-carboxylate 
• 1246193-59-8 C₂₃H₂₇FN₆ 
• 1260242-71-4 C₂₉H₃₁F₆N₇ 
• 1334308-68-7 C₂₄H₃₇N₃O₂ 
• 1227609-55-3 (4-cyclobutylpiperazin-1-yl)(7-(phenylsulfonyl)-7-azaspiro[3.5]nonan-2-yl)methanone 
• 1542135-76-1 1-(1-methyl-6-oxo-1,6-dihydropyridazin-3-yl)piperidin-4-yl 4-cyclobutylpiperazine-1-carboxylate 
• 1000405-21-9 4-(4-cyclobutylpiperazine-1-carbonyl)benzaldehyde 

Relevant articles and documents

Pyrazolo [3,4 - the b] pyridine and [...] composition preparation method and use of (by machine translation)

The present invention provides a pyrazolo [3,4 - the b] pyridine and [...] compound of preparation and use, in particular, the present invention provides a following formula (I) compounds are shown, wherein the definition of each group as described in the specification. The compounds of the invention has excellent tyrosine kinase inhibiting activity, so can be used for preparing a series of treating diseases associated with the tyrosine kinase activity of the drug. (by machine translation)

PIPERAZINE AND AMINOPYRROLIDINE COMPOUNDS AS HISTAMINE H3 RECEPTOR ANTAGONISTS

The invention relates to compounds of formula (I) wherein R1 to R3 and X0, X1, X2 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antago

AZETIDINES AND CYCLOBUTANES AS HISTAMINE H3 RECEPTOR ANTAGONISTS

The invention relates to compounds of formula (I) wherein R, R0, R1, m, n and X1 to X4 have the meaning as cited in the description and the claims. Said compounds are useful as Histamine H3 receptor antagonists. The invention also relates to pharmaceutical compositions, the preparation of such compounds as well as the production and use as medicament.