1328362-87-3Relevant articles and documents
Discovery of potent antiproliferative agents targeting EGFR tyrosine kinase based on the pyrido[3′,2′:4,5]thieno[3,2-d]pyrimidin-4-amine scaffold
Aziz, Yasmine Mohamed Abdel,Said, Mohamed Mokhtar,El Shihawy, Hosam Ahmed,Tolba, Mai Fathy,Abouzid, Khaled Abouzid Mohamed
, p. 1015 - 1028 (2015)
A series of pyridothieno[3,2-d]pyrimidin-4-amines was designed and synthesized as congeners to the classical 4-anilinoquinazolines as ATP-competitive epidermal growth factor receptor (EGFR) inhibitors. Compound 5a exhibited the most potent and selective i