132843-69-7

Basic information

• Product Name: 2-Propen-1-one, 1,1'-(1,3-phenylene)bis[3-(4-methoxyphenyl)-, (E,E)-
• CAS NO: 132843-69-7
• Molecular Formula: C26H22O4
• Molecular Weight: 398.458
• Mol File: 132843-69-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-Propen-1-one, 1,1'-(1,3-phenylene)bis[3-(4-methoxyphenyl)-, (E,E)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Propen-1-one, 1,1'-(1,3-phenylene)bis[3-(4-methoxyphenyl)-, (E,E)-(132843-69-7)
• EPA Substance Registry System: 2-Propen-1-one, 1,1'-(1,3-phenylene)bis[3-(4-methoxyphenyl)-, (E,E)-(132843-69-7)

Safety Data

• Hazardous Substances Data: 132843-69-7(Hazardous Substances Data)

Upstream product

• 6781-42-6 1,3-diacetylbenzene 
• 123-11-5 4-methoxy-benzaldehyde 
• 4481-99-6 3,3'-dioxo-3,3'-m-phenylene-di-propionic acid 

Downstream Products

• 143517-40-2 {3-[(1R,2R,3S)-2-(4-Methoxy-phenyl)-3-phenylsulfanyl-cyclopropanecarbonyl]-phenyl}-[(1R,2R,3S)-2-(4-methoxy-phenyl)-3-phenylsulfanyl-cyclopropyl]-methanone 
• 143517-53-7 {3-[(1S,2R,3S)-2-Benzenesulfonyl-3-(4-methoxy-phenyl)-cyclopropanecarbonyl]-phenyl}-[(1S,2R,3S)-2-benzenesulfonyl-3-(4-methoxy-phenyl)-cyclopropyl]-methanone 
• 132843-91-5 {3-[4-(4-Methoxy-phenyl)-4,5-dihydro-1H-pyrazole-3-carbonyl]-phenyl}-[4-(4-methoxy-phenyl)-4,5-dihydro-1H-pyrazol-3-yl]-methanone 

Relevant articles and documents

Analogues of xanthones——Chalcones and bis-chalcones as α-glucosidase inhibitors and anti-diabetes candidates

Two series of compounds (chalcones and bis-chalcones) were designed, synthesized, and evaluated as α-glucosidase inhibitors (AGIs) with 1-deoxynojirimycin as positive control in vitro. Most of the compounds with two or four hydroxyl groups showed better inhibitory activities than 1-deoxynojirimycin towards α-glucosidase with noncompetitive mechanism. Moreover, most of the hydroxy bis-chalcones exhibit good α-glucosidase inhibitory activities in enzyme test. Inspiringly, bis-chalcones 2g (at 1 μM concentration) has stronger effect than 1-deoxynojirimycin on reducing the glucose level in HepG-2 cells (human liver cancer cell line).