132922-67-9Relevant articles and documents
Synthesis and anti-proliterative in-vitro activity of two natural dihydrostilbenes and their analogues
Zhang, Wei-Ge,Zhao, Rui,Ren, Jian,Ren, Li-Xiang,Lin, Jin-Guang,Liu, Dai-Lin,Wu, Ying-Liang,Yao, Xin-Sheng
, p. 244 - 250 (2008/02/09)
A total synthetic route for two natural dihydrostilbenes with significant cytotoxicity toward human cancer cell lines, (3-(2-(7-methoxybenzo[d][1,3] dioxol-5-yl)ethyl)phenol 1a and 6-(3-hydroxyphenethyl)benzo[d][1,3]dioxol-4-ol 1b), which were isolated from Bulbophyllum odoratissimum Lind1, was developed via Wittig-Horner reaction. The natural products 1a and 1b were obtained in 28% and 20% overall yield, respectively. Additionally, nine analogues, 1c-1k, of the two natural dihydrostilbenes were synthesized and evaluated for their anti-proliferative activity against human SGC-7901, KB and HT-1080 cell lines by MTT assay. The activities of 1c and 1d were in the same range as those of the natural products 1a and 1b.