132923-57-0Relevant articles and documents
Marine natural products. XXIII. Three new cytotoxic dimeric macrolides, swinholides B and isoswinholide A, congeners of swinholide A, from the Okinawan marine sponge Theonella swinhoei
Kobayashi,Tanaka,Katori,Kitagawa
, p. 2960 - 2966 (1990)
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The total synthesis of swinholide A. Part 4: Synthesis of swinholide A and isoswinholide A from the protected monomeric seco acid, pre-swinholide A
Paterson, Ian,Yeung, Kap-Sun,Ward, Richard A.,Smith, Julian D.,Cuimming, John G.,Lamboley, Serge
, p. 9467 - 9486 (2007/10/02)
Swinholide A and isoswinholide A were synthesized in 7 steps from the fully protected seco acid 4. Key steps include: (i) bimolecular acylation, 7 + 10 → 12, (ii) selective hydrolysis of the methyl ester, 16 → 17, and (iii) regioselective macrolactonisati