132974-84-6

Basic information

• Product Name: 2-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-, (S)-
• CAS NO: 132974-84-6
• Molecular Formula: C28H33NO4SSi
• Molecular Weight: 507.726
• Mol File: 132974-84-6.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-, (S)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-, (S)-(132974-84-6)
• EPA Substance Registry System: 2-Pyrrolidinone, 5-[[[(1,1-dimethylethyl)diphenylsilyl]oxy]methyl]-1-[(4-methylphenyl)sulfon yl]-, (S)-(132974-84-6)

Safety Data

• Hazardous Substances Data: 132974-84-6(Hazardous Substances Data)

Upstream product

• 74936-93-9 (S)-5-oxopyrrolidine-2-carbonyl chloride 
• 4931-66-2 methyl (S)-pyroglutamate 
• 58479-61-1 tert-butylchlorodiphenylsilane 
• 132974-83-5 (5S)-5-[[(tert-butyldiphenylsilyl)oxy]methyl]pyrrolidin-2-one 
• 98-59-9 p-toluenesulfonyl chloride 
• 98-79-3 L-Pyroglutamic acid 
• 17342-08-4 (S)-Pyroglutaminol 

Downstream Products

• 1269425-81-1 (1R,4S,7S)-4-((tert-butyldiphenylsilyloxy)methyl)-3-tosyl-8-oxa-3-azabicyclo[5.1.0]octane 
• 1500059-31-3 (2S,5R)-2-{[(tert-butyldiphenylsilyl)oxy]methyl}-5-ethynyl-1-tosylpyrrolidine 
• 1500059-33-5 C₃₀H₃₅NO₃SSi 
• 1500059-25-5 N-{(2S)-1-[(tert-butyldiphenylsilyl)oxy]-5-hydroxyhept-6-yn-2-yl}-4-methylbenzenesulfonamide 
• 132974-88-0 (2S,3R,4S)-5-(tert-Butyl-diphenyl-silanyloxy)-3-ethyl-2-hydroxy-4-(toluene-4-sulfonylamino)-pentanoic acid 
• 132974-87-9 (3S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-ethyl-3-hydroxy-1-(toluene-4-sulfonyl)-pyrrolidin-2-one 
• 132974-92-6 (2S,3S,4R,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-ethyl-1-(toluene-4-sulfonyl)-pyrrolidine-2,3-diol 
• 132992-81-5 C₃₀H₃₇NO₅SSi 
• 132974-86-8 (4S,5S)-5-(tert-Butyl-diphenyl-silanyloxymethyl)-4-ethyl-1-(toluene-4-sulfonyl)-pyrrolidin-2-one 
• 132975-04-3 (2R,3S)-4-(tert-Butyl-diphenyl-silanyloxy)-2-ethyl-3-(toluene-4-sulfonylamino)-butyric acid 
• 132974-90-4 (3R,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-ethyl-1-(toluene-4-sulfonyl)-azetidin-2-one 
• 132974-89-1 N-[(1S,2R)-1-(tert-Butyl-diphenyl-silanyloxymethyl)-2-formyl-butyl]-4-methyl-benzenesulfonamide 
• 132974-91-5 (3R,4S)-4-(tert-Butyl-diphenyl-silanyloxymethyl)-3-ethyl-azetidin-2-one 
• 143264-79-3 (2R,5R)-2-Methoxy-1-(toluene-4-sulfonyl)-5-((E)-5-trimethylsilanyl-pent-4-enyl)-pyrrolidine 

Relevant articles and documents

Convergent synthesis of (-)-quinocarcin based on the combination of sonogashira coupling and gold(I)-catalyzed 6-endo-dig hydroamination

The total synthesis of the pentacyclic tetrahydroisoquinoline alkaloid quinocarcin, which possesses intriguing structural and biological features, has been achieved through a gold(I)-catalyzed regioselective hydroamination reaction. It is noteworthy that the regioselectivity of the intramolecular hydroamination of an unsymmetrical alkyne could be completely switched through substrate control. Other key features of this synthesis include the highly stereoselective synthesis of 2,5-cis-pyrrolidine through the intramolecular amination of the bromoallene and the Lewis acid mediated ring opening of dihydrobenzofuran. Golden(I): A convergent asymmetric total synthesis of quinocarcin employed Sonogashira and Au-catalyzed hydroamination reactions (see scheme). The regioselectivity of the intramolecular hydroamination of an unsymmetrical alkyne was switched by substrate control. Copyright

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The synthesis of 4'-t-butylcarbamyl- and 4'-p-toluenesulphonamidyl-2',3'- dideoxy pyrimidine nucleoside analogues

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