1329797-47-8Relevant articles and documents
Efficient synthesis of impurity-C of antimigraine agent Rizatriptan benzoate
Pramanik, Chinmoy,Bhumkar, Rahul,Karhade, Ganesh,Khairnar, Pravinkumar,Tripathy, Narendra Kumar,Gurjar, Mukund K.
, p. 507 - 511 (2012)
During the commercial manufacturing of antimigraine drug Rizatriptan benzoate, several impurities are reported to be formed. This present work demonstrates a convergent and short synthesis of the most critical impurity (C) of Rizatriptan, [2-(5-((1H-1,2,4-triazol-1-yl)methyl)-1H-indole-2-yl)-N,N- dimethylethanamine (1)], recently reported in U.S. Pharmacopeia.