132982-03-7

Basic information

• Product Name: 2-(3¹,4¹-dimethoxyphenyl)quinazol-4-one
• Synonyms: 2-(3¹,4¹-dimethoxyphenyl)quinazol-4-one
• CAS NO: 132982-03-7
• Molecular Weight: 282.299
• Mol File: 132982-03-7.mol
• Article Data: 38

Chemical Properties

• CAS DataBase Reference: 2-(3¹,4¹-dimethoxyphenyl)quinazol-4-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(3¹,4¹-dimethoxyphenyl)quinazol-4-one(132982-03-7)
• EPA Substance Registry System: 2-(3¹,4¹-dimethoxyphenyl)quinazol-4-one(132982-03-7)

Safety Data

• Hazardous Substances Data: 132982-03-7(Hazardous Substances Data)

Upstream product

• 610-15-1 2-nitrobenzamide 
• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 201230-82-2 carbon monoxide 
• 2859-78-1 4-Bromoveratrole 
• 28144-70-9 anthranilic acid amide 
• 552-89-6 2-nitro-benzaldehyde 
• 5763-61-1 3,4-dimethoxybenzylamine 
• 144-62-7 oxalic acid 
• 88-65-3 2-bromobenzoic-acid 
• 119072-55-8 tert-butylisonitrile 
• 75113-82-5 N-(2-bromophenyl)-3,4-dimethoxybenzamide 
• 40728-72-1 2-(3,4-dimethoxyphenyl)-4H-benzo[d][1,3]oxazin-4-one 
• 118-92-3 anthranilic acid 
• 126492-17-9 2,3-dihydro-2-(3,4-dimethoxyphenyl)quinazolin-4(1H)-one 

Relevant articles and documents

Aerobic oxidative synthesis of quinazolinones and benzothiazoles in the presence of laccase/DDQ as a bioinspired cooperative catalytic system under mild conditions

The current study applied laccase/DDQ as a bioinspired cooperative catalytic system for the synthesis of quinazolinones (80-95% yield) and benzothiazoles (65-98% yield) using air or O2 as ideal oxidants in aqueous media at ambient temperature. The aerobic oxidative cyclization reactions occur in two steps: (i) chemical cyclization; (ii) chemoenzymatic oxidation. These methods are more environment-friendly, efficient, simple and practical than other reported methods due to the use of O2 as an oxidant, laccase as an eco-friendly biocatalyst, aqueous media as the solvent and free from any toxic transition metal and halide catalysts. Therefore, these methods can be applied in pharmaceutical and other sensitive synthetic procedures.

A magnetically retrievable copper ionic liquid nanocatalyst for cyclooxidative synthesis of 2-phenylquinazolin-4(3: H)-ones

In the present work, we report the design and fabrication of a copper-containing ionic liquid supported magnetic nanocatalyst via a convenient and straightforward synthetic approach for the formation of 2-phenylquinazolin-4(3H)-ones using o-aminobenzamide and benzaldehydes as the reaction partners. The successful formation and properties of the as-prepared catalyst have been thoroughly investigated using diverse physico-chemical techniques including FT-IR, XRD, FE-SEM, TEM, ICP, VSM, BET and TGA. Using this nanocatalytic system, a variety of 2-phenylquinazolin-4(3H)-ones are synthesized in excellent yields with operational ease and short reaction times in an environmentally preferable solvent under open air and without using any external oxidizing agent. Besides, the catalyst possessed facile magnetic recoverability and remarkable reusability for six consecutive runs without any appreciable decrease in the catalytic efficiency.

Antioxidant and ros inhibitory activities of heterocyclic 2-aryl-4(3h)-quinazolinone derivatives

Background: Antioxidants are small molecules that prevent or delay the process of oxidations caused by highly reactive free radicals. These molecules are known for their ability to protect various cellular architecture and other biomolecules from oxidative stress and free radicals. Thus, antioxidants play a key role in the prevention of oxidative damages caused by highly reactive free radicals. Methods: In the present study, a series of previously synthesized heterocyclic 2-aryl-4(3H)-quinazolinone derivatives 1-25 were screened for antioxidant activity by employing in vitro DPPH and superoxide anion radical scavenging activities. ROS inhibitory activities were also evaluated by serum-opsonized zymosan activated whole blood phagocytes and isolated neutrophils. Cytotoxicity studies were carried out by employing an MTT assay against the 3T3 cell line. Results: Most of the 2-aryl-4(3H)-quinazolinone derivatives showed potent antioxidant activities in superoxide anion radical scavenging assay with IC50 value ranging between 0.57 μM-48.93 μM, as compared to positive control quercetin dihydrate (IC50 = 94.1 ± 1.1 μM ). Compounds 5, 6, and 14 showed excellent activity in DPPH assay. Compounds 5-8, 12-15, 17, and 20 showed promising activities in the ROS inhibition assay. All compounds were found to be non-cytotoxic against the 3T3 cell line. Structure antioxidant activity has been established. Conclusion: It can be concluded that most of the heterocyclic 2-aryl-4(3H)-quinazolinone derivatives 1-25 are identified as promising antioxidant agents that are capable of fighting against free radicals and oxidative stress. Thus, they can serve as a lead towards treating oxidative stress and related pathologies.