133010-18-1

Basic information

• Product Name: Carbamic acid, (2-fluoro-2-oxo-ethyl)-, phenylmethyl ester
• CAS NO: 133010-18-1
• Molecular Formula: C10H10FNO3
• Molecular Weight: 211.193
• Mol File: 133010-18-1.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: Carbamic acid, (2-fluoro-2-oxo-ethyl)-, phenylmethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, (2-fluoro-2-oxo-ethyl)-, phenylmethyl ester(133010-18-1)
• EPA Substance Registry System: Carbamic acid, (2-fluoro-2-oxo-ethyl)-, phenylmethyl ester(133010-18-1)

Safety Data

• Hazardous Substances Data: 133010-18-1(Hazardous Substances Data)

Upstream product

• 1138-80-3 N-(Benzyloxycarbonyl)glycine 

Downstream Products

• 869002-29-9 N-benzyloxycarbonylglycyl-L-4-thia-5,5-dimethylproline 
• 1212-53-9 methyl N-benzyloxycarbonylglycinate 
• 1049736-72-2 4(N),10(N)-bis-[N-(benzyloxycarbonyl)glycyl]-1,7-dimethyl-1,4,7,10-tetraazacyclododecane 
• 869001-98-9 dibenzyl N-benzyloxycarbonyl-glycyl-L-2-allylprolyl-L-glutamate 
• 915958-44-0 dibenzyl (2S,5'R)-2-[1'-(2''-benzyloxycarbonylamino-acetyl)-8'-hydroxy-6'-oxo-1',7'-diazaspiro[4.4]non-7'-yl]-pentanedioate 
• 869001-96-7 dibenzyl N-benzyloxycarbonyl-glycyl-L-2-ethylprolyl-L-glutamate 
• 869002-11-9 dibenzyl (2S,5'R)-2-[1'-(2''-benzyloxycarbonylamino-acetyl)-6'-oxo-1',7'-diazaspiro[4.4]non-7'-yl]-pentanedioate 
• 869002-32-4 dibenzyl N-benzyloxycarbonyl-glycyl-L-4-thia-5,5-dimethylprolyl-L-glutamate 
• 869001-88-7 N-benzyloxycarbonyl-glycyl-L-2-allylproline 
• 869001-82-1 methyl N-benzyloxycarbonyl-glycyl-L-2-allylprolinate 
• 869001-87-6 N-benzyloxycarbonyl-glycyl-L-2-ethylproline 
• 869001-81-0 methyl N-benzyloxycarbonyl-glycyl-L-2-ethylprolinate 
• 869001-86-5 N-benzyloxycarbonyl-glycyl-L-2-methylproline 
• 847952-40-3 (S)-methyl 1-(2-(((benzyloxy)carbonyl)amino)acetyl)-2-methylpyrrolidine-2-carboxylate 

Relevant articles and documents

Metal-free approach for hindered amide-bond formation with hypervalent iodine(iii) reagents: application to hindered peptide synthesis

A new bio-inspired approach is reported for amide and peptide synthesis using α-amino esters that possess a potential activating group (PAG) at the ester residue. To activate the ester functionality under mild metal-free conditions, we exploited the facile dearomatization of phenols with hypervalent iodine(iii) reagents. Using a pyridine-hydrogen fluoride complex, highly reactive acyl fluoride intermediates can be successfully generated, thereby allowing for the smooth formation of sterically hindered amides and peptides from bulky amines and α-amino esters, respectively.

Duality of mechanism in the tetramethylfluoroformamidinium hexafiuorophosphate-mediated synthesis of N-benzyloxycarbonylamino acid fluorides

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Amino acid fluorides: Their preparation and use in peptide synthesis

Z or Fmoc amino acid fluorides have been prepared from the protected amino acids and cyanuric fluoride, and have been tested both in the condensation with simple amino acid esters and in Solid Phase Peptide Synthesis.