133040-06-9 Usage
Description
Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate, with the CAS number 133040-06-9, is a complex organic compound characterized by its oily chemical properties. It is primarily recognized for its utility in the field of organic synthesis, where it serves as a valuable intermediate or building block for the creation of more complex molecules.
Uses
Used in Organic Synthesis:
Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate is used as a synthetic intermediate for the development of various organic compounds. Its unique structure and functional groups make it a versatile component in the synthesis of pharmaceuticals, agrochemicals, and other specialty chemicals.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate is used as a key component in the synthesis of novel drug candidates. Its incorporation into drug molecules can potentially enhance their therapeutic properties, such as improving bioavailability, targeting specific receptors, or exhibiting enhanced efficacy against certain diseases.
Used in Agrochemical Industry:
Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate is also utilized in the agrochemical industry for the development of new pesticides, herbicides, and other crop protection agents. Its unique chemical structure can contribute to the creation of more effective and environmentally friendly products.
Used in Specialty Chemicals:
In the specialty chemicals sector, Methyl (E)-3-[2-Butyl-1-[(4-Carbomethoxyphenyl)methyl]imidazol-5-yl]-2-(2-thienylmethyl)-2-propenoate is employed as a building block for the synthesis of various high-value chemicals. These can include dyes, fragrances, and other additives used in a wide range of applications, from the textile industry to the cosmetics sector.
Check Digit Verification of cas no
The CAS Registry Mumber 133040-06-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,0,4 and 0 respectively; the second part has 2 digits, 0 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 133040-06:
(8*1)+(7*3)+(6*3)+(5*0)+(4*4)+(3*0)+(2*0)+(1*6)=69
69 % 10 = 9
So 133040-06-9 is a valid CAS Registry Number.
133040-06-9Relevant articles and documents
Potent Nonpeptide Angiotensin II Receptor Antagonists. 2. (1-Carboxybenzyl)imidazole-5-acrylic Acids
Keenan, Richard M.,Weinstock, Joseph,Finkelstein, Joseph A.,Franz, Robert G.,Gaitanopoulos, Dimitri E.,et al.
, p. 1880 - 1892 (2007/10/02)
The further evolution of the imidazole-5-acrylic acid series of nonpeptide angiotensin II receptor antagonists is detailed (for Part 1, see: J.Med.Chem. 1992, 35, 3858).Modifications of the N-benzyl ring substitution were undertaken in an effort to mimic the Tyr4 residue of angiotensin II.Introduction of a p-carboxylic acid on the N-benzyl ring resulted in the discovery of compounds with nanomolar affinity for the receptor and good oral activity.SAR studies of these potent antagonists revealed that the thienyl ring, the (E)-acrylic acid, and the imidazole ring in addition to the two acid groups were important for high potency.Also, overlay comparisons of the parent diacid with both angiotensin II and a representative biphenylyltetrazole nonpeptide angiotensin II receptor antagonist are presented.The parent diacid analog, SKF 108566 or (E)-3--2-propenoic acid, is currently in clinical development for the treatment of hypertension.
1-(Carboxybenzyl)imidazole-5-acrylic Acids: Potent and Selective Angiotensin II Receptor Antagonists
Weinstock, Joseph,Keenan, Richard M.,Samanen, James,Hempel, Judith,Finkelstein, Joseph A.,et al.
, p. 1514 - 1517 (2007/10/02)
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