133059-44-6

Basic information

• Product Name: 4-Bromo-3-fluorobenzonitrile
• Synonyms: 3-FLUORO-4-BROMOBENZONITRILE;4-BROMO-3-FLUOROBENZONITRILE;4-Bromo-3-fluorobenzonitrile97%;4-Cyano-2-fluorobromobenzene
• CAS NO: 133059-44-6
• Molecular Formula: C₇H₃BrFN
• Molecular Weight: 200.01
• Product Categories: Aromatic Nitriles;Fluorine series
• Mol File: 133059-44-6.mol
• Article Data: 4

Chemical Properties

• Melting Point: 54-58 C
• Boiling Point: 230.1 °C at 760 mmHg
• Flash Point: 93 °C
• Appearance: /
• Density: 1.69 g/cm³
• Vapor Pressure: 0.067mmHg at 25°C
• Refractive Index: 1.577
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 4-Bromo-3-fluorobenzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Bromo-3-fluorobenzonitrile(133059-44-6)
• EPA Substance Registry System: 4-Bromo-3-fluorobenzonitrile(133059-44-6)

Safety Data

• Hazard Codes: T,Xi,Xn
• Statements: 20/21/22-36/37/38-36-22
• Safety Statements: 26-36
• HazardClass: IRRITANT
• Hazardous Substances Data: 133059-44-6(Hazardous Substances Data)

Usage

Chemical Properties

White to light brown solid

InChI:InChI=1/C7H3BrFN/c8-6-2-1-5(4-10)3-7(6)9/h1-3H

Upstream product

• 63069-50-1 4-cyano-2-fluoroaniline 
• 7787-70-4 copper(I) bromide 
• 367-24-8 4-bromo-2-fluoroaniline 
• 64248-62-0 3,4-Difluorobenzonitrile 
• 133059-43-5 4-bromo-3-fluorobenzaldehyde 

Downstream Products

• 133059-43-5 4-bromo-3-fluorobenzaldehyde 
• 133302-62-2 4-bromo-3-fluorobenzamidine hydrogen chloride 
• 176508-81-9 4-cyano-3-fluorobenzoic acid 
• 1369898-90-7 3-tert-butoxy-4-bromobenzonitrile 
• 1035235-29-0 3-fluoro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile 
• 916213-60-0 4-bromo-3-hydroxybenzonitrile 
• 693232-05-2 3-benzyloxy-4-bromobenzonitrile 
• 105942-10-7 3-fluoro-4-formylbenzonitrile 
• 1352812-53-3 C₂₅H₂₅FN₄O₄S 
• 1352812-55-5 C₂₅H₂₃FN₄O₄S 
• 1352813-03-6 C₂₀H₁₇FN₄O₂S*ClH 
• 1363148-60-0 3-fluoro-4-(2-methylpyridin-4-yl)benzonitrile 
• 1370362-89-2 C₂₁H₉Br₃F₃N₃ 
• 1383718-61-3 (rac)-3-fluoro-4-((7-methyl-5-oxo-5,6,7,8-tetrahydroquinazolin-2-yl)amino)benzonitrile 

Relevant articles and documents

Preparation method of 4-cyano-2-fluorobenzyl alcohol

The invention discloses a preparation method of 4-cyano-2-fluorobenzyl alcohol, and belongs to the technical field of medical intermediates. 3, 4-difluorobenzonitrile is adopted as a raw material and reacts with potassium bromide in the presence of a phase transfer catalyst, or 3-fluoro-4-bromobenzaldehyde and hydroxylamine are subjected to a dehydration reaction to obtain 3-fluoro-4-bromobenzonitrile, and then the 3-fluoro-4-bromobenzonitrile is subjected to Grignard reagent exchange and reacts with paraformaldehyde to obtain the 4-cyano-2-fluorobenzyl alcohol. The method is safe and stable, the obtained product is easy to purify, and the method has potential industrial amplification prospects.

NOVEL GPR119 AGONIST COMPOUNDS

The present invention relates to novel compounds of formula (I), process for preparation of the same and composition comprising these compounds.