133089-17-5Relevant articles and documents
Lysine 2,3-Aminomutase: Role of S-Adenosyl-L-methionine in the Mechanism. Demonstration of Tritium Transfer from (2RS,3RS)-Lysine to S-Adenosyl-L-methionine
Kilgore, James L.,Aberhart, D. John
, p. 79 - 84 (2007/10/02)
(2RS,3RS)-Lysine has been synthesized, and incubated with lysine 2,3-aminomutase in the presence of S-adenosyl-L-methionine (SAM).After incubation, the SAM was converted, by heating, into methylthioadenosine (MTA).The latter contained ca. 1-6percent of the incubated tritium, consistent with an exchange of SAM hydrogens (probably at C-5') with the 3-pro-R hydrogen of lysine.The results support a mechanism for lysine 2,3-aminomutase in which SAM acts as hydrogen carrier.