133092-34-9 Usage
Description
4-Chloro-5,6,7,8-tetrahydroquinoline is a chlorinated tetrahydroquinoline derivative with the molecular formula C9H10ClN. It belongs to a class of organic compounds that have a cyclohexane fused to a piperidine. This synthetic compound is not found naturally and is mainly utilized in research and experimental studies.
Uses
Used in Pharmaceutical Industry:
4-Chloro-5,6,7,8-tetrahydroquinoline is used as a chemical intermediate for the development of pharmaceuticals due to its unique structure and potential biological activities. Its synthesis and properties make it a valuable compound for chemists and researchers in the field of organic and medicinal chemistry.
Used in Agrochemical Industry:
4-Chloro-5,6,7,8-tetrahydroquinoline is also used as a precursor in the synthesis of agrochemicals, where its specific chemical properties can contribute to the development of new products for agricultural applications.
Check Digit Verification of cas no
The CAS Registry Mumber 133092-34-9 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,0,9 and 2 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 133092-34:
(8*1)+(7*3)+(6*3)+(5*0)+(4*9)+(3*2)+(2*3)+(1*4)=99
99 % 10 = 9
So 133092-34-9 is a valid CAS Registry Number.
133092-34-9Relevant articles and documents
Novel Aminoquinoline Derivatives Significantly Reduce Parasite Load in Leishmania infantum Infected Mice
Konstantinovi?, Jelena,Videnovi?, Milica,Orsini, Stefania,Bogojevi?, Katarina,D'Alessandro, Sarah,Scaccabarozzi, Diletta,Terzi? Jovanovi?, Nata?a,Gradoni, Luigi,Basilico, Nicoletta,?olaja, Bogdan A.
, p. 629 - 634 (2018/05/15)
In this Letter, a detailed analysis of 30 4-aminoquinoline-based compounds with regard to their potential as antileishmanial drugs has been carried out. Ten compounds demonstrated IC50 50 1 μM against intramacrophage L. infantum amastigotes. Two compounds showed dose-dependent enhancement of NO and ROS production by bone marrow-derived macrophages and remarkable reduction of parasite load in vivo, with advantage of being short-term and orally active. To the best of our knowledge, this is the first example of 4-amino-7-chloroquinoline derivatives active in Leishmania infantum infected mice.
