1331769-86-8

Basic information

• Product Name: N-benzenesulfonylmatrinic acid
• Synonyms: N-benzenesulfonylmatrinic acid
• CAS NO: 1331769-86-8
• Molecular Weight: 406.546
• Mol File: 1331769-86-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: N-benzenesulfonylmatrinic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-benzenesulfonylmatrinic acid(1331769-86-8)
• EPA Substance Registry System: N-benzenesulfonylmatrinic acid(1331769-86-8)

Safety Data

• Hazardous Substances Data: 1331769-86-8(Hazardous Substances Data)

Upstream product

• 1331769-92-6 matrinic acid diphenylmethyl ester 
• 519-02-8 (+)-matrine 
• 519-08-4 matrinic acid 
• 109616-04-8 C₁₆H₂₈N₂O₂ 
• 98-09-9 benzenesulfonyl chloride 

Relevant articles and documents

Preparation of Matrinic/Oxymatrinic Amide Derivatives as Insecticidal/Acaricidal Agents and Study on the Mechanisms of Action against Tetranychus cinnabarinus

In continuation of our program to develop natural-product-based pesticidal candidates, matrinic/oxymatrinic amides were obtained through structural optimization of matrine. N′-(4-Fluoro)phenyl-N-(4-bromo)phenylsulfonyloxymatrinic amide (IIm) showed potent

Construction and synthesis of tricyclic matrinic derivatives against influenza A virus by privileged structure strategy

A series of new matrinic derivatives with an 11-adamantyl group were designed, synthesized and evaluated for their anti-influenza A H3N2 activities, based on the privileged structure strategy. SAR analysis indicated that introduction of an 11-adamantyl by ester linker might be helpful for the activity. Among them, compound 7b exhibited promising anti-H3N2 activities with IC50 value of 5.14 μM, slightly better than that of amantadine. Its activity was further confirmed at the protein level. In primary mechanism, compound 7b could inhibit virus replication cycle at early stage by targeting M2 protein, consistent with that of amantadine. This study represents a successful application of combined strategy of privileged amantadine segment for further structural optimization and development of a new class of anti-influenza agents.

MATRINIC ACID/ MATRINE DERIVATIVES AND PREPARATION METHODS AND USES THEREOF

The present invention relates to a N-substituted matrinic acid derivative or matrine derivative, and its preparation method and uses. Specifically, the present invention relates to a compound of Formula (I) or (II) (wherein all the definitions of substituted groups are those mentioned in the specification), or a pharmaceutically acceptable salt, geometric isomer, stereoisomer, solvate, ester or prodrug thereof. The present invention further relates to a method for preparing the compound of the present invention, a pharmaceutical composition containing the compound, and uses thereof in manufacture of a medicament. The compound of the present invention can be used for prophylaxis and/or treatment of a disease or disorder associated with viral infection such as hepatitis B and/orhepatitis C and/orAIDS.