1331779-63-5Relevant articles and documents
Synthesis and anti-tubercular evaluation of some novel pyrazolo[3,4-d] pyrimidine derivatives
Trivedi, Amit R.,Dholariya, Bipin H.,Vakhariya, Chintan P.,Dodiya, Dipti K.,Ram, Haresh K.,Kataria, Vipul B.,Siddiqui, Arif B.,Shah, Viresh H.
, p. 1887 - 1891 (2012/11/14)
A series of phenothiazine clubbed pyrazolo[ 3,4-d]pyrimidines have been synthesized by using the Biginelli multi-component cyclocondensation reaction and their ability to inhibit growth of Mycobacterium tuberculosis in vitro have been determined. The results show that compounds 4b, 4d, and 4f exhibited excellent anti-tubercular activity with percentage inhibition of 93, 91, and 96, respectively, at a minimum inhibitory concentration (MIC) of a MIC of >6.25 lg/ml. Springer Science+Business Media, LLC 2011.