133230-46-3

Basic information

• Product Name: 3-amino-3-benzylpyrrolidin-2-one
• Synonyms: 3-amino-3-benzylpyrrolidin-2-one
• CAS NO: 133230-46-3
• Molecular Weight: 190.245
• Mol File: 133230-46-3.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 3-amino-3-benzylpyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 3-amino-3-benzylpyrrolidin-2-one(133230-46-3)
• EPA Substance Registry System: 3-amino-3-benzylpyrrolidin-2-one(133230-46-3)

Safety Data

• Hazardous Substances Data: 133230-46-3(Hazardous Substances Data)

Upstream product

• 63526-79-4 methyl 2-isocyano-3-phenylpropanoate 
• 141408-63-1 N-(trifluoroacetyl)-α-allylphenylalaninamide 
• 133230-43-0 N-(trifluoroacetyl)-L-phenylalanine allyl ester 
• 350-09-4 N-trifluoroacetyl-L-phenylalanine 
• 63-91-2 L-phenylalanine 
• 133230-45-2 3-benzyl-2-oxo-3-(trifluoroacetamido)-pyrrolidine 

Downstream Products

• 133230-47-4 N-(Boc-Asp(OBn))-3-amino-3-benzyl-2-oxopyrrolidine 

Relevant articles and documents

Heteroannulation of Arynes with α-Amino Imides: Synthesis of 2,2-Disubstituted Indolin-3-ones and Application to the Enantioselective Total Synthesis of (+)-Hinckdentine A

A novel heteroannulation reaction between α-amino imides and in situ generated arynes has been developed for the synthesis of 2,2-disubstituted indolin-3-ones. An enantioselective total synthesis of the marine alkaloid (+)-hinckdentine A was subsequently accomplished using this reaction as a key step. A catalytic enantioselective Michael addition of an α-aryl-α-isocyanoacetate to phenyl vinyl selenone was employed for the construction of the enantioenriched α-quaternary α-amino ester.