1332507-57-9

Basic information

• Product Name: 3-(3',5'-di-O-tert-butyldimethylsilyl-d-ribofuranosyl)-9-(2-N-benzylcarbamylethoxy)-1,3-diaza-7-hydroxy-2-oxophenoxadine
• Synonyms: 3-(3',5'-di-O-tert-butyldimethylsilyl-d-ribofuranosyl)-9-(2-N-benzylcarbamylethoxy)-1,3-diaza-7-hydroxy-2-oxophenoxadine
• CAS NO: 1332507-57-9
• Molecular Weight: 755.028
• Mol File: 1332507-57-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 3-(3',5'-di-O-tert-butyldimethylsilyl-d-ribofuranosyl)-9-(2-N-benzylcarbamylethoxy)-1,3-diaza-7-hydroxy-2-oxophenoxadine(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(3',5'-di-O-tert-butyldimethylsilyl-d-ribofuranosyl)-9-(2-N-benzylcarbamylethoxy)-1,3-diaza-7-hydroxy-2-oxophenoxadine(1332507-57-9)
• EPA Substance Registry System: 3-(3',5'-di-O-tert-butyldimethylsilyl-d-ribofuranosyl)-9-(2-N-benzylcarbamylethoxy)-1,3-diaza-7-hydroxy-2-oxophenoxadine(1332507-57-9)

Safety Data

• Hazardous Substances Data: 1332507-57-9(Hazardous Substances Data)

Upstream product

• 6161-23-5 1-(3,5-di-O-acetyl-β-D-2-deoxyribofuranosyl)-5-bromouracil 
• 16600-92-3 1,3,5-Trihydroxy-2-nitrobenzene 
• 108-73-6 3,5-dihydroxyphenol 
• 1332507-67-1 N-[4-(2-N-benzylcarbamylethoxy-4,6-dihydroxyphenyl)]-2'-deoxy-5-bromouridine 
• 1332507-65-9 3',5'-di-O-acetyl-N-[4-(2-N-benzylcarbamyl-ethoxy-6-hydroxy-4-O-pivaloylphenyl)]-2'-deoxy-5-bromouridine 
• 1332507-64-8 3',5'-di-O-acetyl-N-[4-(2,6-dihydroxy-4-O-pivaloylphenyl)]-2'-deoxy-5-bromouridine 
• 1332507-68-2 4-O-pivaloyl-2-aminophloroglucinol 
• 1332507-70-6 3',5'-di-O-tert-butyldimethylsilyl-N-[4-(2-N-benzylcarbamylethoxy-4,6-O-tert-butyldimethylsilylphenyl)]-2'-deoxy-5-bromouridine 

Downstream Products

• 1332507-58-0 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-O-trifluoromethylsulfonyl-2-oxophenoxadine 
• 1332507-59-1 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-phenyl-2-oxophenoxadine 
• 1332507-60-4 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(1-naphthyl)-2-oxophenoxadine 
• 1332507-61-5 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-methoxyphenyl)-2-oxophenoxadine 
• 1332507-62-6 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(4-cyanophenyl)-2-oxophenoxadine 
• 1332507-63-7 3-(3',5'-di-O-tert-butyldimethylsilyl-D-ribofuranosyl)-9-(2-N-benzylcarbamyl-ethoxy)-1,3-diaza-7-(thiophenyl-2-yl)-2-oxophenoxadine 

Relevant articles and documents

Optimization of fluorescence property of the 8-oxodGclamp derivative for better selectivity for 8-oxo-2′-deoxyguanosine

2′-Deoxyguanosine (dG) suffers from oxidation by reactive oxygen species (ROS) to form 8-oxo-2′-deoxyguanosine (8-oxo-dG), which is regarded as a marker of oxidative stress in the cells. In our continuous study for the recognition molecule of 8-oxo-dG, 8-oxoGclamp and its derivatives have been identified as the selective fluorescent probe. However, it is an obstacle for further application that dG also forms a complex with 8-oxoGclamp, resulting in fluorescence quenching in less polar solvents. Quenching of the fluorescence of 8-oxoGclamp is thought to involve photo-induced electron transfer in the complex. It was hypothesized that the energy level of the excited state of 8-oxoGclamp and the HOMO energy of dG are the preliminary determinant of the quenching efficiency. Thus, fluorescence properties of the substituted derivatives at the 7-position of the 1,3-diazaphenoxazine part of 8-oxoGclamp were investigated. Among the new derivatives, fluorescence of the 7-phenyl substituted 8-oxoGclamp was not quenched by dG even in the stable complex, exhibiting the highest selectivity for 8-oxo-dG.