1332525-41-3Relevant articles and documents
Coupling reaction between electron-rich pyrimidinones and α-amino acids promoted by phosphonium salts
Elmarrouni, Abdelatif,Fabrellas, Josep M.,Heras, Montserrat
experimental part, p. 5967 - 5977 (2011/10/09)
Coupling reaction between electron-rich 2-morpholino-4(3H)-pyrimidinone and nucleophilic side chains of several natural α-amino acids promoted by phosphonium salt has been developed to prepare new optically active pyrimidin-4-yl amino acids. The best results were obtained using a two-step method through the easily available benzotriazolyl-1-oxy intermediate. A detailed optimization study of this reaction is discussed.