133271-00-8

Basic information

• Product Name: (R)-3-phenyl-3-hydroxypropanal
• Synonyms: (R)-3-phenyl-3-hydroxypropanal
• CAS NO: 133271-00-8
• Molecular Weight: 150.177
• Mol File: 133271-00-8.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: (R)-3-phenyl-3-hydroxypropanal(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-phenyl-3-hydroxypropanal(133271-00-8)
• EPA Substance Registry System: (R)-3-phenyl-3-hydroxypropanal(133271-00-8)

Safety Data

• Hazardous Substances Data: 133271-00-8(Hazardous Substances Data)

Upstream product

• 85551-57-1 (R)-1-Phenylbut-3-en-1-ol 
• 100-52-7 benzaldehyde 
• 75-07-0 acetaldehyde 
• 1452591-09-1 (R,E)-3-(4-hydroxy-4-phenylbut-1-en-1-yl)cyclohex-2-en-1-one 
• 181227-42-9 (+)-(R)-1-phenylbut-3-en-1-yl acetate 
• 80735-94-0 1-Phenyl-3-buten-1-ol 

Downstream Products

• 5381-93-1 (4R)-4-hydroxy-4-phenylbutan-2-one 
• 115290-81-8 (R)-N-methyl-3-phenyl-3-hydroxypropylamine 
• 103548-16-9 (R)-3-phenyl-1,3-dihydroxypropane 
• 2768-42-5 (R)-3-phenyl-3-hydroxypropionic acid 

Relevant articles and documents

Highly efficient enzymatic resolution of homoallyl alcohols leading to a simple synthesis of optically pure fluoxetine and related compounds

A practical method for enzymatic resolution of homoallyl alcohols and its utility in the synthesis of optically pure fluoxetine and related compounds is reported.

A site isolation-enabled organocatalytic approach to enantiopure γ-amino alcohol drugs

Solid support-enabled site isolation has previously allowed to use paraldehyde as an acetaldehyde surrogate in aldol reactions. However, only electron-poor aldehydes were tolerated by the system. Herein, we show that the temporary conversion of benzaldehyde into η6-benzaldehyde Cr(CO)3 circumvents this limitation. Asymmetric synthesis of (R)-Phenoperidine, as well as formal syntheses of (R)-Fluoxetine and (R)-Atomoxetine, illustrate the benefits of this strategy.

A diarylprolinol in an asymmetric, catalytic, and direct crossed-aldol reaction of acetaldehyde

(Chemical Equation Presented) No over-reacting: A diarylprolinol was found to be an effective organocatalyst of the direct, enantioselective aldol reaction of acetaldehyde, affording β-hydroxy α-unsubstituted aldehydes in good yield with excellent enantio