1333118-34-5 Usage
Description
(9R)-9-isothiocyanato-Cinchonan, an isothiocyanate derivative of cinchonan, is a chemical compound with a molecular formula of C19H22N2O and a molecular weight of 294.39 g/mol. As a chiral molecule, it exhibits a specific rotation of +74.2° (c=0.5, CHCl3). (9R)-9-isothiocyanato-Cinchonan is known for its applications in organic synthesis, particularly as a chiral ligand for asymmetric catalysis, and is also utilized in the preparation of chiral catalysts and pharmaceutical intermediates. Furthermore, (9R)-9-isothiocyanato-Cinchonan has been investigated for its potential medicinal properties, which include anti-inflammatory and anti-cancer activities.
Uses
Used in Organic Synthesis:
(9R)-9-isothiocyanato-Cinchonan is used as a chiral ligand in asymmetric catalysis for enhancing the selectivity and efficiency of various chemical reactions. Its unique stereochemistry allows for the creation of enantiomerically pure products, which are essential in the pharmaceutical industry.
Used in Pharmaceutical Industry:
(9R)-9-isothiocyanato-Cinchonan is used as a key intermediate in the synthesis of various pharmaceutical compounds. Its chiral nature enables the development of drugs with improved efficacy and reduced side effects.
Used in Medicinal Applications:
(9R)-9-isothiocyanato-Cinchonan is studied for its potential as an anti-inflammatory agent, which could be beneficial in treating conditions characterized by inflammation, such as arthritis and other autoimmune diseases.
Additionally, it is explored for its anti-cancer properties, with potential applications in the development of novel therapeutic strategies against various types of cancer.
Check Digit Verification of cas no
The CAS Registry Mumber 1333118-34-5 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,3,3,3,1,1 and 8 respectively; the second part has 2 digits, 3 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1333118-34:
(9*1)+(8*3)+(7*3)+(6*3)+(5*1)+(4*1)+(3*8)+(2*3)+(1*4)=115
115 % 10 = 5
So 1333118-34-5 is a valid CAS Registry Number.
1333118-34-5Relevant articles and documents
D-Mannitol-derived novel chiral thioureas: Synthesis and application in asymmetric Henry reactions
Liu, Miaoxi,Ji, Nan,Wang, Li,Liu, Peng,He, Wei
, p. 999 - 1004 (2018/02/23)
Five novel thioureas have been obtained through multi-step reactions from D-Mannitol as starting material and applied as catalysts in the asymmetric Henry reaction. Using catalyst 7a, (1S,2R)-2-nitro-1-phenylpropan-1-ol containing two chiral centers was o
Modular bifunctional chiral thioureas as versatile organocatalysts for highly enantioselective aza-Henry reaction and michael addition
Li, Hua,Zhang, Xu,Shi, Xin,Ji, Nan,He, Wei,Zhang, Shengyong,Zhang, Bangle
, p. 2264 - 2274 (2012/11/06)
A series of new modular bifunctional chiral thiourea organocatalysts were synthesized from natural Cinchona alkaloids and amino acids, and their performance in the aza-Henry reaction of nitroalkanes to imines, the Michael addition of acetylacetone to nitroolefins and the Michael addition of acetone to nitroolefins was investigated. Under the mild conditions, the important building blocks β-nitro amines and γ-nitro carbonyl compounds could be obtained in good yields (up to 95%) with excellent enantioselectivities (up to 99% ee) and diastereoselectivity (up to 17:1). Copyright
