1333231-44-9

Basic information

• Product Name: benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate
• Synonyms: benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate
• CAS NO: 1333231-44-9
• Molecular Weight: 403.478
• Mol File: 1333231-44-9.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate(1333231-44-9)
• EPA Substance Registry System: benzyl ((S)-4-methyl-1-oxo-1-(((S)-1-oxo-3-(2-oxopyrrolidin-3-yl)propan-2-yl)amino)pentan-2-yl)carbamate(1333231-44-9)

Safety Data

• Hazardous Substances Data: 1333231-44-9(Hazardous Substances Data)

Upstream product

• 61-90-5 L-leucine 
• 100-51-6 benzyl alcohol 
• 30293-88-0 N-carbonyl-L-leucine methyl ester 
• 2018-66-8 Z-Leu-OH 
• 51021-87-5 N-benzyloxycarbonyl-L-leucine methyl ester 
• 7517-19-3 methyl (L)-leucinate hydrochloride 
• 1385184-01-9 C₈H₁₄N₂O₃*ClH 
• 1333231-43-8 C₂₁H₃₁N₃O₅ 
• 1350624-48-4 C₂₂H₃₁N₃O₆ 
• 1350624-45-1 C₁₃H₂₂N₂O₅ 

Downstream Products

• 1333231-50-7 C₂₅H₃₆N₄O₆ 
• 1350624-56-4 C₂₅H₃₈N₄O₆ 
• 1385183-93-6 C₂₄H₃₂N₄O₆ 
• 1385183-94-7 C₂₄H₃₂N₄O₅S 
• 1385183-82-3 benzyl ((S)-1-(((S)-4-(cyclopropylamino)-3,4-dioxo-1-(2-oxopyrrolidin-3-yl)butan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)-carbamate 
• 1385183-73-2 C₂₆H₃₈N₄O₈ 
• 1385183-84-5 C₂₆H₃₆N₄O₈ 
• 1385183-74-3 C₂₈H₄₂N₄O₆ 
• 1416992-39-6 sodium (2S)-2-((S)-2-(((benzyloxy)carbonyl)amino)-4-methylpentanamido)-1-hydroxy-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate 
• 1385183-69-6 C₂₅H₃₆N₄O₆ 
• 1467641-77-5 C₂₁H₃₂N₃O₈P 
• 1467641-73-1 C₂₅H₄₀N₃O₈P 

Relevant articles and documents

Structure-guided design and optimization of dipeptidyl inhibitors of norovirus 3CL protease. Structure-activity relationships and biochemical, X-ray crystallographic, cell-based, and in vivo studies

Norovirus infection constitutes the primary cause of acute viral gastroenteritis. There are currently no vaccines or norovirus-specific antiviral therapeutics available for the management of norovirus infection. Norovirus 3C-like protease is essential for viral replication, consequently, inhibition of this enzyme is a fruitful avenue of investigation that may lead to the emergence of antinorovirus therapeutics. We describe herein the optimization of dipeptidyl inhibitors of norovirus 3C-like protease using iterative SAR, X-ray crystallographic, and enzyme and cell-based studies. We also demonstrate herein in vivo efficacy of an inhibitor using the murine model of norovirus infection.

Potent inhibition of norovirus by dipeptidyl α-hydroxyphosphonate transition state mimics

The design, synthesis, and evaluation of a series of dipeptidyl α-hydroxyphosphonates is reported. The synthesized compounds displayed high anti-norovirus activity in a cell-based replicon system, as well as high enzyme selectivity.

Potent inhibition of norovirus 3CL protease by peptidyl α-ketoamides and α-ketoheterocycles

Series of structurally-diverse α-ketoamides and α- ketoheterocycles was synthesized and subsequently investigated for inhibitory activity against Norwalk virus 3C protease in vitro, as well as anti-norovirus activity in a cell-based replicon system.