133365-44-3

Basic information

• Product Name: Pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H,6H)-dione, 7,8-dihydro- (9CI)
• Synonyms: Pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H,6H)-dione, 7,8-dihydro- (9CI);7,8-dihydro-Pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H,6H)-dione
• CAS NO: 133365-44-3
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.13868
• Product Categories: TRIAZINE
• Mol File: 133365-44-3.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• Density: 1.76±0.1 g/cm3(Predicted)
• PKA: 8.44±0.20(Predicted)
• CAS DataBase Reference: Pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H,6H)-dione, 7,8-dihydro- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H,6H)-dione, 7,8-dihydro- (9CI)(133365-44-3)
• EPA Substance Registry System: Pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H,6H)-dione, 7,8-dihydro- (9CI)(133365-44-3)

Safety Data

• Hazardous Substances Data: 133365-44-3(Hazardous Substances Data)

Upstream product

• 7544-75-4 2-iminopyrrolidine-hydrochloride 
• 5843-43-6 phenyl isocyanatoformate 

Downstream Products

• 133364-77-9 3-[2-[4-[Bis(4-fluorophenyl)-methylene]piperidin-1-yl]ethyl]-7,8-dihydro-2H,6H,pyrrolo[1,2-a]-1,3,5-triazine-2,4(3H)-dione 

Relevant articles and documents

Heterocyclic compound having serotonine 2-receptor antagonistic activity

A heterocyclic compound represented by formula (I): STR1 wherein R1 represents a hydrogen atom, an alkyl group, an aryl group which may be substituted with one or more substituents selected from the group consisting of a halogen atom, an alkoxy group, an alkyl group and a trihalogenomethyl group; λ represents 0 or 1; ring A represents a 6 membered heterocyclic ring containing the nitrogen atom shared with the triazine ring and which may contain one or more double bonds; Y represents a substituted or unsubstituted alkylene group having 1 to 15 carbon atoms; and Q represents a group represented by formula (II): STR2 wherein R2, R3, R4 and R5 are represented by substituents disclosed herein; or salt thereof, and intermediates therefor are described. The compound of formula (I) or salt thereof exhibit selective serotonin 2-receptor antagonistic activity and are useful for the prevention or treatment of circulatory diseases, e.g., ischemic heart diseases, cerebral vessel disturbances, and peripheral circulation disturbances.