133384-77-7

Basic information

• Product Name: 2-fluoro-2-benzyloxymethylmalonic acid diethyl ester
• Synonyms: 2-fluoro-2-benzyloxymethylmalonic acid diethyl ester
• CAS NO: 133384-77-7
• Molecular Weight: 298.311
• Mol File: 133384-77-7.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2-fluoro-2-benzyloxymethylmalonic acid diethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: 2-fluoro-2-benzyloxymethylmalonic acid diethyl ester(133384-77-7)
• EPA Substance Registry System: 2-fluoro-2-benzyloxymethylmalonic acid diethyl ester(133384-77-7)

Safety Data

• Hazardous Substances Data: 133384-77-7(Hazardous Substances Data)

Upstream product

• 3587-60-8 Benzyloxymethyl chloride 
• 685-88-1 fluoromalonic acid diethyl ester 

Downstream Products

• 133384-79-9 2,2-dimethyl-5-benzyloxymethyl-5-fluoro-1,3-dioxane 
• 133384-78-8 2-benzyloxymethyl-2-fluoro-1,3-propanediol 

Relevant articles and documents

Method for preparing 3-fluorooxetane-3-methanol and intermediate of 3-fluorooxetane-3-methanol

The invention discloses a method for preparing 3-fluorooxetane-3-methanol and an intermediate of 3-fluorooxetane-3-methanol. The method comprises the following steps of: performing a cyclization reaction on a compound represented by a formula 5 and strong base in organic solvent so as to obtain a compound represented by a formula 6, wherein R1 is a methylsulfonyl group or a p-methylphenylsulfonylgroup or a p-trifluoromethylbenzenesulfonyl group or a trifluoromethylsulfonyl group; preforming a reaction on magnesium and the compound represented by the formula 6 in organic solvent so as to obtain a compound 7. The method has the advantages of being high in yield, simple to operate and simple in post-treatment, and is suitable for large-scale production.

SYNTHESIS OF 5,5'-DIHYDROXYLEUCINE AND 4-FLUORO-5,5'-DIHYDROXYLEUCINE, THE REDUCTION PRODUCTS OF 4-CARBOXYGLUTAMIC AND 4-CARBOXY-4-FLUOROGLUTAMIC ACIDS

Schemes for the synthesis of 5,5'-dihydroxyleucine 3 and its 4-fluoro analog 7 involving the condensation of a suitable 'aminoacid moiety' with 2,2-dimethyl-5-iodomethyl-1,3-dioxane 15D or its fluoro analog 27A were tested.The anion of the ethyl N-diphenylmethylene-glycinate 25 gave better yields of 3 than the classical anion of diethyl acetamidomalonate.This strategy could not be successfully applied to the synthesis of 7, which could be prepared by reduction of a suitably protected 4-fluoro-4-carboxyglutamate with BMS.