133393-02-9

Basic information

• Product Name: 2-(2-fluorophenyl)-1,3-dioxolane
• Synonyms: 2-(2-fluorophenyl)-1,3-dioxolane
• CAS NO: 133393-02-9
• Molecular Weight: 168.168
• Mol File: 133393-02-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 2-(2-fluorophenyl)-1,3-dioxolane(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(2-fluorophenyl)-1,3-dioxolane(133393-02-9)
• EPA Substance Registry System: 2-(2-fluorophenyl)-1,3-dioxolane(133393-02-9)

Safety Data

• Hazardous Substances Data: 133393-02-9(Hazardous Substances Data)

Usage

Physical state

Colorless liquid It is a liquid at room temperature and is colorless in appearance.

Origin

Derived from the dioxolane family The compound is based on a six-membered cyclic structure containing both oxygen and carbon atoms.

Functional group

2-fluorophenyl The presence of this group provides unique chemical properties and makes it useful in various industrial applications.

Primary uses

Solvent, manufacturing of pharmaceuticals, and other organic compounds It serves as a solvent and is used in the production of various medicines and organic compounds.

Low toxicity

Relatively low toxicity The compound is not highly toxic, making it a safer option for use in certain processes and products.

Environmental impact

Low 2-(2-fluorophenyl)-1,3-dioxolane has a relatively low environmental impact, making it a more eco-friendly choice for certain applications.

Upstream product

• 107-21-1 ethylene glycol 
• 446-52-6 2-Fluorobenzaldehyde 

Downstream Products

• 1122103-32-5 C₁₄H₁₇FO₃ 
• 486-84-0 harmane 
• 180335-34-6 (E)-3-(2-Diphenylphosphanyl-phenyl)-acrylic acid ethyl ester 
• 171514-35-5 [(2-Diphenylphosphanyl-phenyl)-hydroxy-methyl]-phosphonic acid dimethyl ester 
• 50777-76-9 (2-formylphenyl)(diphenyl)phosphine 
• 50777-73-6 2-(ortho-diphenylphosphinophenyl)-1,3-dioxolane 

Relevant articles and documents

Water Soluble Phosphanes, XIV [1]. Hydrophilic Derivatives of Triphenylphosphane with NH2, COOH and P(O)(OR)2 Functionalized Side Chains

Nucleophilic phosphanylation of ortho-fluorophenylacetic acid or ortho-fluorobenzylamine with PhPH2 using KOtBu as the base affords the hydrophilic tertiary phosphanes 3 and 4a with terminal CH2-COOH and CH2-NH2 substituents. The corresponding secondary phosphane ligands 2 or 5 may be obtained by Pd-catalyzed P-C coupling of ortho-iodophenylacetic acid with PhPH2 or selective nucleophilic phosphanylation of ortho-fluorophenylacetic acid. Novel phosphonatomethyl derivatives 7a, 7b of triphenylphosphane have been obtained in a two stage synthesis using ortho-iodobenzylchloride or meta-iodobenzylbromide as starting materials. Arbusov reaction with P(OEt)3 and Pd-catalyzed P-C coupling reactions with Ph2PH gave the esters 7a, 7b. Purification of 7a was achieved via its BH3 adduct 8a. Deprotection, hydrolysis and neutralisation with NaOH affords the water soluble sodium salts 9a,9b. α-Hydroxy and α-benzylamino derivatives 12 and 14 of ortho-diphenylphosphanobenzyl phosphonate (e.g. 7a) and the corresponding Me2P(O) analogs 13 and 16 are accessible in a straightforward manner by addition of (MeO)2P(O)H or Me2P(O)H to ortho-phosphanobenzaldehyde 11a or its benzaldimino derivative 15, respectively. An improved synthesis for 11a-11c has been developed. Reaction of 11a with the Wittig reagent Ph3P=C(H)COOEt and subsequent hydrolysis of the intermediate ester 17a affords ortho-diphenylphosphano cinnamic acid 17. The catalytical activity of 1, 9a, 9b and related ligands in Suzuki-type coupling reactions has been investigated.