133420-81-2

Basic information

• Product Name: Cyclohexaneacetic acid, a-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-, ethyl ester, (R)-
• CAS NO: 133420-81-2
• Molecular Formula: C18H36O3Si
• Molecular Weight: 328.568
• Mol File: 133420-81-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Cyclohexaneacetic acid, a-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-, ethyl ester, (R)-(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclohexaneacetic acid, a-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-, ethyl ester, (R)-(133420-81-2)
• EPA Substance Registry System: Cyclohexaneacetic acid, a-[[dimethyl(1,1,2-trimethylpropyl)silyl]oxy]-, ethyl ester, (R)-(133420-81-2)

Safety Data

• Hazardous Substances Data: 133420-81-2(Hazardous Substances Data)

Upstream product

• 53585-93-6 (R)-(-)-hexahydromandelic acid 
• 67373-56-2 chlorodimethyl(1,1,2-trimethylpropyl)silane 
• 106975-25-1 ethyl (R)-2-hydroxy-2-cyclohexylacetate 

Downstream Products

• 133420-93-6 [(R)-2-Cyclohexyl-2-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-eth-(Z)-ylidene]-((R)-2-methoxymethyl-pyrrolidin-1-yl)-amine 
• 133420-86-7 (R)-Cyclohexyl-[dimethyl-(1,1,2-trimethyl-propyl)-silanyloxy]-acetaldehyde 

Relevant articles and documents

Synthesis of O-Protected (R)-2-Hydroxy Aldehyde and Their Hydrocyanation

The synthesis of O-silyl- and O-benzyl-protected (R)-2-hydroxy aldehydes (R)-6 from (R)-2-hydroxy carboxylic acids (R)-1 is described.While attempts for their diastereoselective hydrocyanation with hydrocyanic acid and (R)-oxynitrilase as catalyst have not been successful, the cyano silylation with trimethylsilyl cyanide occurred diastereoselectively with a ratio of 81:19 preferring the threo form without racemization at C-2 of the 2-hydroxy aldehyde. Key Words : (R)-2-Hydroxy aldehydes, O-protected / Hydrocyanation