1334287-93-2

Basic information

• Product Name: (S)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline
• Synonyms: (S)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline
• CAS NO: 1334287-93-2
• Molecular Weight: 281.277
• Mol File: 1334287-93-2.mol
• Article Data: 5

Chemical Properties

• CAS DataBase Reference: (S)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline(1334287-93-2)
• EPA Substance Registry System: (S)-4-methoxy-N-(2,2,2-trifluoro-1-phenylethyl)aniline(1334287-93-2)

Safety Data

• Hazardous Substances Data: 1334287-93-2(Hazardous Substances Data)

Upstream product

• 104-94-9 4-methoxy-aniline 
• 3262-89-3 triphenylboroxine 
• 1005385-31-8 N-(2,2,2-trifluoro-1-methoxyethyl)-4-methoxyaniline 
• 202869-51-0 4-methoxy-N-(2,2,2-trifluoro-1-phenylethylidene)benzenamine 
• 14796-89-5 4-methoxy-N-(triphenylphosphoran-ylidene)-aniline 
• 434-45-7 2,2,2-Trifluoroacetophenone 

Downstream Products

• 128404-37-5 (S)-2,2,2-trifluoro-1-phenylethan-1-amine hydrochloride 

Relevant articles and documents

Catalytic Asymmetric Reduction of α-Trifluoromethylated Imines with Catecholborane by BINOL-Derived Boro-phosphates

A catalytic enantioselective reduction of α-trifluoromethylated imines by a BINOL-derived boro-phosphate employing catecholborane as hydride source has been developed. This method provides an efficient route to prepare synthetically useful chiral α-triflu

Palladium(II)-catalyzed enantioselective synthesis of α- (trifluoromethyl)arylmethylamines

Trifluoromethylacetaldimines, generated in situ from the corresponding N,O-acetals, undergo 1,2-addition of arylboroxines under palladium(II) catalysis to generate a variety of α-(trifluoromethyl)arylmethylamines with good to high enantioselectivity (up to 97% ee). The pyridine-oxazolidine (PyOX) class of ligands was found to be particularly suitable for this transformation, which proceeds without exclusion of ambient air and moisture.

Chiral phosphoric acid catalyzed transfer hydrogenation: Facile synthetic access to highly optically active trifluoromethylated amines

Amines to an end: Highly optically active α-CF3- functionalized amines can be obtained using metal-free reaction conditions. The method involves the transfer hydrogenation of CF3-substituted ketimines catalyzed by 1 and reductive ami