1334386-80-9Relevant articles and documents
Discovery of N-(1-adamantyl)-2-(4-alkylpiperazin-1-yl)acetamide derivatives as T-type calcium channel (Cav3.2) inhibitors
Giordanetto, Fabrizio,Knerr, Laurent,Selmi, Nidhal,Llins, Antonio,Lindqvist, Anders,Wang, Qing-Dong,Sthlberg, Pernilla,Thorstensson, Fredrik,Ullah, Victoria,Nilsson, Kristina,O'Mahony, Gavin,Hoegberg, Got,Lindhardt, Emma,Strand, Annika,Duker, Goeran
, p. 5557 - 5561 (2011)
Chemical evolution of a HTS-based fragment hit resulted in the identification of N-(1-adamantyl)-2-[4-(2-tetrahydropyran-4-ylethyl)piperazin-1- yl]acetamide, a novel, selective T-type calcium channel (Cav3.2) inhibitor with in vivo antihypertensive effect in rats.