1334400-26-8Relevant articles and documents
Discovery of potent and selective thienopyrimidine inhibitors of Aurora kinases
McClellan, William J.,Dai, Yujia,Abad-Zapatero, Cele,Albert, Daniel H.,Bouska, Jennifer J.,Glaser, Keith B.,Magoc, Terry J.,Marcotte, Patrick A.,Osterling, Donald J.,Stewart, Kent D.,Davidsen, Steven K.,Michaelides, Michael R.
, p. 5620 - 5624 (2011/10/12)
In an effort to discover Aurora kinase inhibitors, an HTS hit revealed an amide containing pyrrolopyrimidine compound. Replacement of the pyrrolopyrimidine residue with a thienopyrimidine moiety led to a series of potent and selective Aurora inhibitors.
