133444-83-4

Basic information

• Product Name: (R)-benzyl (1-(methylthio)-3-oxopropan-2-yl)carbamate
• Synonyms: (R)-benzyl (1-(methylthio)-3-oxopropan-2-yl)carbamate
• CAS NO: 133444-83-4
• Molecular Weight: 253.322
• Mol File: 133444-83-4.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-benzyl (1-(methylthio)-3-oxopropan-2-yl)carbamate(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-benzyl (1-(methylthio)-3-oxopropan-2-yl)carbamate(133444-83-4)
• EPA Substance Registry System: (R)-benzyl (1-(methylthio)-3-oxopropan-2-yl)carbamate(133444-83-4)

Safety Data

• Hazardous Substances Data: 133444-83-4(Hazardous Substances Data)

Upstream product

• 95406-97-6 N-[(benzyloxy)carbonyl]-S-methyl-L-cysteine 
• 501-53-1 benzyl chloroformate 

Downstream Products

• 133401-06-6 [(R)-1-(6-Methoxy-2,3,4,9-tetrahydro-1H-β-carbolin-1-yl)-2-methylsulfanyl-ethyl]-carbamic acid benzyl ester 
• 133419-81-5 [(R)-1-(6-Methoxy-9H-β-carbolin-1-yl)-2-methylsulfanyl-ethyl]-carbamic acid benzyl ester 

Relevant articles and documents

α-Amino Aldehydes as Readily Available Chiral Aldehydes for Rh-Catalyzed Alkyne Hydroacylation

Readily available α-amino aldehydes, incorporating a methylthiomethyl (MTM) protecting group on nitrogen, are shown to be efficient substrates in Rh-catalyzed alkyne hydroacylation reactions. The reactions are performed under mild conditions, employing a small-bite-angle bis-phosphine ligand, allowing for good functional group tolerance with high stereospecificity. Amino aldehydes derived from glycine, alanine, valine, leucine, phenylalanine, isoleucine, serine, tryptophan, methionine, and cysteine were successfully employed, as was an enantiomerically enriched α-OMTM-aldehyde derived from phenyllactic acid. The synthetic utility of the α-amino enone products is demonstrated in a short enantioselective synthesis of the natural product sphingosine.