1334524-25-2

Basic information

• Product Name: [2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid
• Synonyms: [2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid
• CAS NO: 1334524-25-2
• Molecular Weight: 456.743
• Mol File: 1334524-25-2.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: [2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: [2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid(1334524-25-2)
• EPA Substance Registry System: [2-({5-oxo-5-[(triisopropylsilyl)oxy]pentan-2-yl}disulfanyl)phenyl]acetic acid(1334524-25-2)

Safety Data

• Hazardous Substances Data: 1334524-25-2(Hazardous Substances Data)

Upstream product

• 1334524-24-1 triisopropylsilyl 4-(pyridine-2-yldisulfanyl)pentanoate 
• 39161-85-8 alpha-mercaptophenylacetic acid 

Downstream Products

• 1334524-26-3 C₆₇H₉₃NO₁₈S₂Si 
• 1613697-61-2 C₁₉H₂₀O₄S₂ 
• 1613697-49-6 C₆₂H₇₆N₂O₂₀S₂ 
• 1613697-62-3 C₂₃H₂₃NO₆S₂ 
• 1613697-50-9 C₄₁H₄₆N₆O₉S₂ 
• 1613697-63-4 C₂₇H₃₆N₄O₆S₂ 
• 1613697-57-6 C₄₅H₆₂N₁₀O₈S₃ 
• 1334524-27-4 C₅₈H₇₃NO₁₈S₂ 
• 1613697-59-8 C₃₃H₃₀N₂O₇S₂ 
• 1613697-58-7 C₄₂H₅₀N₂O₇S₂Si 
• 1613697-60-1 C₂₈H₄₀O₄S₂Si 

Relevant articles and documents

THERAPEUTIC AGENT FOR TREATING TUMORS

The present disclosure relates to a therapeutic agent of the formula: Z-C(=O)-(CH2)n-?-S-S-(CRR')m-(CH2)p-C(=O)- NH-(CH2)q-NH-Y[NH-(CH2)r-X-T-W][NH-(CH2-CH-O)t (CH2)s-NH-V] Formula I or a pharmaceutically acceptable salt thereof, useful for treating tumors, including cancers. Where the compound of Formula I also contains a radionuclide or an imaging agent or both, the compound of formula I is a theranostic agent useful for treating and diagnosing tumors, including cancers.

Targeted and armed oncolytic adenovirus via chemoselective modification

Oncolytic adenoviruses (Ads) are an emerging alternative therapy for cancer; however, clinical trial have not yet demonstrated sufficient efficacy. When oncolytic Ads are used in combination with taxoids a synergistic increase in both cytotoxicity and viral replication is observed. In order to generate a next generation oncolytic adenovirus, virion were physically conjugated to a highly potent taxoid, SB-T-1214, and a folate targeting motif. Conjugation was enabled via the metabolic incorporation of non-canonical monosaccharides (O-GlcNAz) and amino acids (homopropargylglycine), which served as sites for chemoselective modification.