1334674-88-2

Basic information

• Product Name: (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol
• Synonyms: (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol
• CAS NO: 1334674-88-2
• Molecular Formula: C₇H₆BrN₃O
• Molecular Weight: 228.05
• Mol File: 1334674-88-2.mol
• Article Data: 10

Chemical Properties

• Appearance: /
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol(CAS DataBase Reference)
• NIST Chemistry Reference: (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol(1334674-88-2)
• EPA Substance Registry System: (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol(1334674-88-2)

Safety Data

• Hazardous Substances Data: 1334674-88-2(Hazardous Substances Data)

Usage

Description

(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol is a pyrrolopyrazine derivative that is brominated at the 2-position and has a methanol group attached to the 7-position. This chemical compound serves as a versatile building block in the synthesis of biologically active molecules, including pharmaceutical drugs and agrochemicals. Its potential biological activities and utility as a research tool in medicinal chemistry and chemical biology are of interest, although further studies are required to fully elucidate its properties and applications.

Uses

Used in Pharmaceutical Industry:
(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol is used as a synthetic building block for the development of pharmaceutical drugs. Its unique structure allows for the creation of novel compounds with potential therapeutic effects, contributing to the advancement of medicine.
Used in Agrochemical Industry:
In the agrochemical field, (2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol is utilized as a component in the synthesis of agrochemicals. Its incorporation into these products can lead to the development of new pesticides or herbicides with improved efficacy and selectivity.
Used as a Research Tool in Medicinal Chemistry:
(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol serves as a valuable research tool in medicinal chemistry. It aids scientists in understanding the structure-activity relationships of biologically active molecules and can be instrumental in the design and optimization of new drug candidates.
Used as a Research Tool in Chemical Biology:
(2-bromo-5H-pyrrolo[2,3-b]pyrazin-7-yl)methanol also has applications in chemical biology, where it can be employed to study the interactions between small molecules and biological targets. This can provide insights into the mechanisms of action and potential applications of related compounds in biological systems.

Upstream product

• 875781-43-4 2-bromo-5H-pyrrolo[2,3-b]pyrazine 
• 1334674-87-1 (2-bromo-5-hydroxymethyl-5H-pyrrolo[2,3-b]pyrazin-7-yl)-methanol 
• 50-00-0 formaldehyd 

Downstream Products

• 1185428-32-3 2-bromo-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde 
• 1185428-34-5 2-bromo-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo-[2,3-b]pyrazine-7-carbaldehyde 
• 1334675-22-7 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde 
• 1334675-23-8 2-phenoxy-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid 
• 1334674-52-0 2-[1-(2,5-Difluoro-phenyl)-1H-imidazol-4-yl]-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyano-azetidin-1-yl)-1-cyclopropyl-2-oxo-ethyl]amide 
• 1334675-75-0 2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carbaldehyde 
• 1334675-76-1 2-[1-(2,5-difluoro-phenyl)-1H-imidazol-4-yl]-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid 
• 1334673-38-9 2-phenoxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-methyl-1-(pyrrolidine-1-carbonyl)propyl]amide 
• 1334673-85-6 2-cyclopropyl-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide 
• 1334674-10-0 2-cyclohexyloxy-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-cyanopiperidine-1-carbonyl)-2,2-dimethylpropyl]amide 
• 1334674-79-1 2-(2-methyl-1-phenyl-1H-imidazol-4-yl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide 
• 1334674-80-4 2-(4-trifluoromethylphenyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-(3-cyanoazetidin-1-yl)-1-cyclopropyl-2-oxoethyl]amide 
• 1334675-19-2 2-cyclopropyl-5-(2-trimethylsilanyl-ethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-1-(4-hydroxy-4-phenylpiperidine-1-carbonyl)-2,2-dimethylpropyl]amide 
• 1334675-24-9 2-phenoxy-5-(2-trimethylsilanylethoxymethyl)-5H-pyrrolo[2,3-b]pyrazine-7-carboxylic acid [(R)-2-methyl-1-(pyrrolidine-1-carbonyl)propyl]amide 

Relevant articles and documents

DIARYL MACROCYCLES AS MODULATORS OF PROTEIN KINASES

The present invention relates to certain diaryl macrocyclic compounds, pharmaceutical compositions containing them, and methods of using them, including methods for treating cancer, pain, neurological diseases, autoimmune diseases, and inflammation.

Its use as an inhibitor and JAK and SYK deriv. pyrroropyrazine

The present invention relates to the use of novel pyrrolopyrazine derivatives of Formula I, wherein the variables Q, R2, R3, and Y are defined as described herein, which inhibit JAK and SYK and are useful for the treatment of auto-immune and inflammatory diseases.

Pyrrolopyrazines as selective spleen tyrosine kinase inhibitors

We describe the discovery of several pyrrolopyrazines as potent and selective Syk inhibitors and the efforts that eventually led to the desired improvements in physicochemical properties and human whole blood potencies. Ultimately, our mouse model revealed unexpected toxicity that precluded us from further advancing this series.