13349-90-1

Basic information

• Product Name: 1-(2,2,2-TRIFLUOROETHYL)PIPERAZINE
• Synonyms: Piperazine, 1-(2,2,2-trifluoroethyl)-
• CAS NO: 13349-90-1
• Molecular Formula: C₆H₁₁F₃N₂
• Molecular Weight: 168.16
• Mol File: 13349-90-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 146.529 °C at 760 mmHg
• Flash Point: 42.42 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 4.617mmHg at 25°C
• Refractive Index: 1.392
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 8.85±0.10(Predicted)
• CAS DataBase Reference: 1-(2,2,2-TRIFLUOROETHYL)PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2,2,2-TRIFLUOROETHYL)PIPERAZINE(13349-90-1)
• EPA Substance Registry System: 1-(2,2,2-TRIFLUOROETHYL)PIPERAZINE(13349-90-1)

Safety Data

• Hazardous Substances Data: 13349-90-1(Hazardous Substances Data)

Usage

General Description

1-(2,2,2-Trifluoroethyl)piperazine is a chemical compound that is used in the synthesis of various pharmaceuticals and agrochemicals. It is a piperazine derivative with a trifluoroethyl group attached to the nitrogen atom. 1-(2,2,2-Trifluoroethyl)piperazine is commonly utilized as a building block in the production of drugs and pesticides due to its ability to participate in various chemical reactions, such as nucleophilic substitution and imine formation. It is also used as a reagent in the preparation of novel organic compounds with potential biological activity. Additionally, 1-(2,2,2-Trifluoroethyl)piperazine has attracted attention for its potential use as a ligand in coordination chemistry and as a substrate in catalytic reactions.

InChI:InChI=1/C6H11F3N2/c7-6(8,9)5-11-3-1-10-2-4-11/h10H,1-5H2

Upstream product

• 13349-91-2 1-(2,2,2-trifluoroethyl)piperazine hydrochloride 
• 629625-96-3 benzyl 4-(2,2,2-trifluoroethyl)piperazine-1-carboxylate 
• 692058-21-2 4-(2,2,2-trifluoroethyl)piperazin-1-carboxylic acid tert-butyl ester 
• 77278-37-6 4-(2,2,2-trifluoroacetyl)piperazine-1-carboxylic acid tert-butyl ester 

Downstream Products

• 252672-44-9 2-[2-Ethoxy-5-(4-(2,2,2-trifluoroethyl)-piperazine-1-sulphonyl)-phenyl]-7-(1-ethylpropyl)-5-methyl-3H-imidazo[5,1-f][1,2,4]triazin-4-one 
• 1296374-20-3 N-methyl-3-nitro-4-[4-(2,2,2-trifluoroethyl)-1-piperazinyl]benzenesulfonamide 
• 1353628-75-7 C₂₅H₂₈Cl₂F₃N₇O₃S 
• 1404536-38-4 C₃₂H₃₅F₃N₆O₃ 

Relevant articles and documents

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Cyclin-dependent kinase inhibitors and application thereof

The invention relates to compounds used as cyclin-dependent kinase inhibitors and application thereof, belonging to the field of medical chemistry. Specifically, the invention provides the compound asshown in a formula I which is described in the specification, or isomers, pharmaceutically acceptable salts, solvates, crystals or prodrugs thereof, preparation methods thereof, pharmaceutical compositions containing the compounds, and application of the compounds or the compositions to treatment of cancer, tissue hyperplasia diseases or inflammatory diseases. The compounds of the invention havegood inhibitory activity to CDK7 and are highly expected to be developed into a therapeutic agent for cancer, tissue hyperplasia diseases and inflammatory diseases.

Aryl alkynyl hydrocarbon compound and preparation method and application thereof

The invention relates to an aryl alkynyl hydrocarbon compound and a medicine compound containing the compound. The compound or the medicine compound can serve as an inhibitor of Retinoid-related orphan receptor gamma t (RORyt). The invention further relates to a method for preparing the compound and the medicine compound and application thereof to mammal treatment or prevention, especially RORyt mediated inflammation of humans or autoimmune diseases.