133503-46-5

Basic information

• Product Name: 1-(o-hydroxy-5-methoxyphenyl)-3-phenylpropargylic alcohol
• Synonyms: 1-(o-hydroxy-5-methoxyphenyl)-3-phenylpropargylic alcohol
• CAS NO: 133503-46-5
• Molecular Weight: 254.285
• Mol File: 133503-46-5.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 1-(o-hydroxy-5-methoxyphenyl)-3-phenylpropargylic alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(o-hydroxy-5-methoxyphenyl)-3-phenylpropargylic alcohol(133503-46-5)
• EPA Substance Registry System: 1-(o-hydroxy-5-methoxyphenyl)-3-phenylpropargylic alcohol(133503-46-5)

Safety Data

• Hazardous Substances Data: 133503-46-5(Hazardous Substances Data)

Upstream product

• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 536-74-3 phenylacetylene 
• 150-76-5 4-methoxy-phenol 
• 4440-01-1 lithium phenylacetylide 

Downstream Products

• 104213-88-9 1-(2-hydroxy-5-methoxyphenyl)-3-phenylpropynone 
• 1248340-79-5 2-benzyl-5-methoxybenzo[b]furan 
• 672-13-9 2-hydroxy-5-methoxybenzaldehyde 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 
• 38216-58-9 (Z)-2-benzylidene-5-methoxybenzofuran-3(2H)-one 
• 26964-24-9 6-methoxyflavone 

Relevant articles and documents

Alkynylation/dearomatizative cyclization to construct spiro[5.5]undecanes

A new access to spiro[5.5]undecane frameworks was reported through the ZnMe2-promoted alkynylation of salicylaldehyde and HCO2H-mediated dearomatizative cyclization which can be used to construct an all-carbon quaternary spirocenter. This method can be applied to the rapid synthesis towards a series of useful motifs of natural products, such as the core of elatol and aphidicolin.

Synthesis of chromones through LiOtBu/air-mediated oxidation and regioselective cyclization of o-hydroxyphenyl propargyl carbinols

A cascade oxidative cyclization reaction for the synthesis of chromone derivatives was developed by using LiOtBu as a mediator and air as an oxidant. The reaction was carried out without the assistance of a transition metal under mild conditions to afford the chromones in good yields with high regioselectivities. A tandem reaction for the synthesis of various chromones was developed. LiOtBu was used as a mediator and air was used as a clean oxidant. The reaction generally showed high regioselectivity under mild conditions. Extensive research showed that dehydrogenative oxidation of the alcohols under strongly basic conditions was the crucial step, and Li+ was also found to play an important role in this process. Copyright

Regioselective synthesis of flavone derivatives via DMAP-catalyzed cyclization of o-alkynoylphenols

A catalytic amount of DMAP promoted cyclization of o-alkynoylphenols via a 6-endo cyclization mode leading to flavone derivatives in high yields without forming 5-exo cyclized aurone derivatives. Utilizing this method, methoxy substituted flavone and alkyl substituted γ-benzopyranone derivatives were synthesized.