133514-43-9

Basic information

• Product Name: ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2
• Synonyms: ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2;H-ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2;EXENDIN 3 (9-39);EXENDIN-3 (9-39) AMIDE;EXENDIN (9-39);EXENDIN (9-39) AMIDE;EXENDIN [9-39] PEPTIDE;EXENDIN FRAGMENT 9-39
• CAS NO: 133514-43-9
• Molecular Formula: C149H234N40O47S
• Molecular Weight: 3369.76
• Product Categories: Peptide;GLP-1 Receptor LigandsObesity Research;Cytokines Growth Factors and Hormones (Obesity);ExendinPeptides for Cell Biology;Hormones;Obesity Peptides;Obesity Research;Other Obesity Research Products;Glucagon receptor and related
• Mol File: 133514-43-9.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.51
• Storage Temp.: −20°C
• Water Solubility: Soluble in water at 1mg/ml
• CAS DataBase Reference: ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2(CAS DataBase Reference)
• NIST Chemistry Reference: ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2(133514-43-9)
• EPA Substance Registry System: ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2(133514-43-9)

Safety Data

• WGK Germany: 3
• RTECS: LF2460000
• Hazardous Substances Data: 133514-43-9(Hazardous Substances Data)

Usage

Description

ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 is a peptide sequence composed of 28 amino acids. It is a truncated form of the exendin-4 peptide and acts as a potent competitive antagonist for the glucagon-like peptide 1 receptor (GLP-1R).

Uses

Used in Biological Research:
ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 is used as a biological probe for studying the function and regulation of the GLP-1 receptor.
Used in Pharmaceutical Industry:
ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 is used as a potent and selective GLP-1 receptor antagonist. It inhibits the binding of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) to their respective receptors, preventing the production of cAMP and modulating insulin secretion.
Used in Neuroscience Research:
ASP-LEU-SER-LYS-GLN-MET-GLU-GLU-GLU-ALA-VAL-ARG-LEU-PHE-ILE-GLU-TRP-LEU-LYS-ASN-GLY-GLY-PRO-SER-SER-GLY-ALA-PRO-PRO-PRO-SER-NH2 is used in neuroscience research to study the role of GLP-1 in regulating feeding behavior. It has been shown to reverse GLP-1 inhibition of feeding behavior in rats when administered in the hypothalamus.

Biochem/physiol Actions

GLP-1 (glucagon-like peptide-1) receptor antagonist. Competitive inhibitor of exendin-3 and exendin-4.