1335147-11-9

Basic information

• Product Name: 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-N-({[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methyl}sulfonyl)benzamide
• CAS NO: 1335147-11-9
• Molecular Weight: 620.212
• Mol File: 1335147-11-9.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-N-({[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methyl}sulfonyl)benzamide(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-N-({[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methyl}sulfonyl)benzamide(1335147-11-9)
• EPA Substance Registry System: 4-{4-[(4'-chlorobiphenyl-2-yl)methyl]piperazin-1-yl}-N-({[(1R,4S)-7,7-dimethyl-2-oxobicyclo[2.2.1]hept-1-yl]methyl}sulfonyl)benzamide(1335147-11-9)

Safety Data

• Hazardous Substances Data: 1335147-11-9(Hazardous Substances Data)

Upstream product

• 916204-05-2 4-(4-((4'-chlorobiphenyl-2-yl)methyl)piperazin-1-yl)benzoic acid 
• 72597-34-3 (+/-)-10-Camphorsulfonamide 

Relevant articles and documents

Lipophilic isosteres of a π-π Stacking interaction: New inhibitors of the Bcl-2-Bak protein-protein interaction

The discovery of new Bcl-2 protein-protein interaction antagonists is described. We replaced the northern fragment of ABT737 (π-π stacking interactions) with structurally simplified hydrophobic cage structures with much reduced conformational flexibility and rotational freedom. The binding mode of the compounds was elucidated by X-ray crystallography, and the compounds showed excellent oral bioavailability and clearance in rat PK studies.