1335290-31-7

Basic information

• Product Name: ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate
• Synonyms: ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate
• CAS NO: 1335290-31-7
• Molecular Weight: 225.195
• Mol File: 1335290-31-7.mol
• Article Data: 2

Chemical Properties

• CAS DataBase Reference: ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate(1335290-31-7)
• EPA Substance Registry System: ethyl 2-(2-cyanophenyl)-2,2-difluoroacetate(1335290-31-7)

Safety Data

• Hazardous Substances Data: 1335290-31-7(Hazardous Substances Data)

Upstream product

• 667-27-6 Ethyl bromodifluoroacetate 
• 2042-37-7 o-cyanobromobenzene 
• 4387-36-4 2-iodobenzonitrile 
• 205865-67-4 α-(trimethylsilyl)difluoroacetic acid ethyl ester 

Downstream Products

• 1824201-60-6 2-cyanobenzenedifluoroacetic acid 
• 799814-30-5 2-(difluoromethyl)benzonitrile 
• 537033-81-1 4,4-difluoro-1,2,3,4-tetrahydroisoquinoline 

Relevant articles and documents

PRMT5 INHIBITORS

The present invention provides a compound of Formula (I) and the pharmaceutically acceptable salts, esters, and prodrugs thereof, which are PRMT5 inhibitors. Also provided are methods of making compounds of Formula I, pharmaceutical compositions comprising compounds of Formula I, and methods of using these compounds to treat cancer, sickle cell, and hereditary persistence of foetal hemoglobin (HPFH) mutations.