133545-25-2 Usage
Description
(S)-(-)-2,2'-Bis(di-p-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl,min.97%, also known as MeOBIPHEP ligand, is an atropisomeric compound that exists in two non-superimposable mirror-image forms. It is an off-white powder and is sold in collaboration with Solvias AG. This ligand is known for its unique chemical properties and is widely used in various applications across different industries.
Uses
Used in Pharmaceutical Industry:
(S)-(-)-2,2'-Bis(di-p-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl,min.97% is used as a chiral ligand in the pharmaceutical industry for the synthesis of enantioselective catalysts. These catalysts are essential for the production of chiral drugs, which have different biological activities and are crucial in the development of new medications.
Used in Chemical Industry:
In the chemical industry, (S)-(-)-2,2'-Bis(di-p-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl,min.97% is used as a ligand in homogeneous catalysis. It plays a vital role in various chemical reactions, such as hydrogenation, hydroformylation, and carbon-carbon bond formation, improving the efficiency and selectivity of these processes.
Used in Agrochemical Industry:
(S)-(-)-2,2'-Bis(di-p-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl,min.97% is employed as a chiral ligand in the agrochemical industry for the synthesis of enantioselective pesticides and herbicides. These enantioselective compounds help in reducing the environmental impact and increasing the effectiveness of these agrochemicals.
Used in Materials Science:
In materials science, (S)-(-)-2,2'-Bis(di-p-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl,min.97% is used as a chiral dopant in the synthesis of chiral materials. These materials have unique optical, electronic, and mechanical properties, making them suitable for various applications, such as sensors, optoelectronics, and nanotechnology.
Used in Analytical Chemistry:
(S)-(-)-2,2'-Bis(di-p-tolylphosphino)-6,6'-dimethoxy-1,1'-biphenyl,min.97% is utilized as a chiral selector in chromatographic techniques, such as high-performance liquid chromatography (HPLC) and gas chromatography (GC). This ligand helps in the separation and analysis of enantiomers, which is crucial in understanding the stereochemistry of various compounds and their biological activities.
Reactions
In many respects the catalytic profile of the MeOBIPHEP ligands is similar to that of other atropisomeric diphosphines such as binap and its many analogs. The nature of the PR2 group strongly influences the catalytic performance of the metal complexes. The rhodium and ruthenium MeO-BIPHEP catalysts are highly effective for the hydrogenation of various C=O, C=C and C=N bonds and several synthetically useful C-C coupling reactions.
Ru and Ir catalyzed dynamic kinetic resolution for the synthesis of hydroxy, amino acid derivatives.
Ru-catalyzed asymmetric hydrogenation of ketones and alkenes.
Ir catalyzed enantioselective hydrogenation of heteroaromatic compounds.
Conjugate addition using 2-heteroaryl titanates and zinc reagents.
Enantio- and regioselective heck-type reaction of aryl boronic acids with 2,3-dihydrofuran
Rhodium-catalyzed carbonyl Z-dienylation.
Rhodium-catalyzed asymmetric 1,4 addition of arylboronic acids to maleimides and enones.
Check Digit Verification of cas no
The CAS Registry Mumber 133545-25-2 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,3,3,5,4 and 5 respectively; the second part has 2 digits, 2 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 133545-25:
(8*1)+(7*3)+(6*3)+(5*5)+(4*4)+(3*5)+(2*2)+(1*5)=112
112 % 10 = 2
So 133545-25-2 is a valid CAS Registry Number.
133545-25-2Relevant articles and documents
Process for producing optically active gamma-butyrolactone
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, (2008/06/13)
This invention provides a novel process for producing optically active 3-hydroxy-γ-butyrolactone in a short step, which is superior economically and in efficiency and industrially suitable by using a starting material which is inexpensive and easily available and reagents easy to handle. This invention relates to a process for producing optically active 3-hydroxy-γ-butyrolactone represented by formula I: wherein the symbol * means an asymmetric carbon atom, which comprises hydrogenating an optically active 4-substituted oxy-3-hydroxybutyrate represented by formula II: wherein R1 represents a C1-4 lower alkyl group, R2 represents a protective group for a hydroxyl group deprotected by hydrogenation with a heterogeneous hydrogenation catalyst, and the symbol * has the same meaning as defined above, in the presence of a heterogeneous hydrogenation catalyst and an acidic substance followed by deprotection and simultaneous ring closure thereof.
Process for preparing oprtically active trimethyllactic acid and its ester
-
, (2008/06/13)
The invention relates to a novel process for preparing optically active trimethyllactic acid and/or its esters by catalytic hydrogenation of trimethylpyruvic acid and/or its esters in the presence of noble metal complex catalysts containing phosphorus ligands.
Asymmetrical hydrogenation
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, (2008/06/13)
There is disclosed a process for the asymmetrical hydrogenation of (E)-2-methyl-3-phenyl-2-propen-1-ol of formula STR1 wherein R1 is as defined herein, to give compounds of formula STR2 The catalyst is a neutral or cationic rhodium complex of a chiral atropisomeric phosphine.
