13355-47-0

Basic information

• Product Name: 1-phenyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline
• Synonyms: 1-phenyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline
• CAS NO: 13355-47-0
• Molecular Weight: 285.389
• Mol File: 13355-47-0.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: 1-phenyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline(CAS DataBase Reference)
• NIST Chemistry Reference: 1-phenyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline(13355-47-0)
• EPA Substance Registry System: 1-phenyl-2-phenyl-1,2,3,4-tetrahydroisoquinoline(13355-47-0)

Safety Data

• Hazardous Substances Data: 13355-47-0(Hazardous Substances Data)

Upstream product

• 3340-78-1 2-phenyl-1,2,3,4-tetrahydroisoquinoline 
• 591-50-4 iodobenzene 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 
• 41852-27-1 2-phenyl-3,4-dihydroisoquinolin-2-ium bromide 
• 100-58-3 phenylmagnesium bromide 
• 98-80-6 phenylboronic acid 
• 103-80-0 phenylacetyl chloride 
• 96718-77-3 N-Phenethyl-N-phenyl-benzamide 
• 1739-00-0 (N-phenyl)phenylethylamine 
• 621-06-7 2,N-diphenylacetamide 
• 103-82-2 phenylacetic acid 
• 1750-36-3 (E)-N-benzylidenebenzenamine 
• 59443-66-2 1,2-diphenyl-1,4-dihydro-2H-isoquinolin-3-one 
• 96719-09-4 1,2-Diphenyl-3,4-dihydro-isoquinolinium; iodide 

Relevant articles and documents

Efficient C(sp 3)-H Bond Arylation of Tetrahydroisoquinolines with Knochel-Type Arylzinc Reagents under Oxidative Conditions

A novel C(sp 3)-H bond arylation of tetrahydroisoquinoline (THIQ) derivatives with Knochel-type arylzinc reagents has been developed. In the presence of MgCl 2, arylzinc reagents readily reacted with THIQ derivatives under oxidative conditions, affording a wide range of potentially biologically active compounds in good yields. Moreover, the developed method can tolerate a variety of sensitive functional groups such as an ester group.

One-pot functionalisation of N-substituted tetrahydroisoquinolines by photooxidation and tunable organometallic trapping of iminium intermediates

Nucleophilic trapping of iminium salts generated via oxidative functionalisation of tertiary amines is well established with stabilised carbon nucleophiles. The few reports of organometallic additions have limited scope of substrate and organometallic nucleophile. We report a novel, one-pot methodology that functionalises N - substituted tetrahydroisoquinolines by visible lightassisted photooxidation, followed by trapping of the resultant iminium ions with organometallic nucleophiles. This affords 1,2-disubstituted tetrahydroisoquinolines in moderate to excellent yields.

Simple and direct sp3 C-H bond arylation of tetrahydroisoquinolines and isochromans via 2,3-dichloro-5,6-dicyano-1,4- benzoquinone oxidation under mild conditions

The 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ)-mediated sp3 C-H bond arylation of tetrahydroisoquinolines and isochromans is described. The corresponding products were facilely synthesized via a simple nucleophilic addition reaction betwee